Teegala, S.B., Sheng, Z., Dalal, M.S., Hirschberg, P.R., Beck, K.D., and V.H. Routh. Lateral hypothalamic orexin glucose-inhibited neurons may regulate reward-based feeding by modulating glutamate transmission in the ventral tegmental area. In press 2018.
Zhou, C., Teegala, S.B., Khan, B., Gonzalez, C. and V.H. Routh. Hypoglycemia: Role of hypothalamic glucose-inhibited (GI) neurons in hypoglycemia detection and correction. Frontiers in Physiology. 9:192 doi: 10.3389/fphys.2018.00192 2018 PMC5854653
Zhou, C and V.H. Routh. Thioredoxin-1 overexpression in the ventromedial nucleus of the hypothalamus (VMH) preserves the counterregulatory response to hypoglycemia during type 1 diabetes mellitus in male rats. Diabetes 2017 67(1): 120-130. PMC5741147
Santiago A. M., Clegg, D.J. and Routh, V.H. Ventromedial hypothalamic glucose sensing and glucose homeostasis vary throughout the estrus cycle. Physiology & Behavior 167: 248-254, 2016. PMC 5159237
Santiago, A. M., Clegg, D.J. and Routh, V.H. Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons. Molecular Metabolism 5(10): 823-833, 2016. PMC 5034617
Hao, L., Sheng, Z., Potian, J.P., Deak, A., Rohowsky-Kochan, C. and V.H. Routh. Lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF03B1) blunt the response of Neuropeptide Y/Agouti-related peptide (NPY/AgRP) glucose inhibited (GI) neurons to decreased glucose. Brain Research, 1648(A): 181-192, 2016. PMC5018455
Sheng, Z., Santiago, A.M., Thomas, M.P. and V.H. Routh. Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry. Mol. Cell. Neurosci. 62:30-41, 2014.
Fioramonti X., Deak, A., Deshpande, S., Carneiro, L., Zhou, C., Sayed, N., Orban, B., Berlin, J.R., Penicaud, L., Leloup, C., Beuve, A. and V. H. Routh. Hypothalamic S-Nitrosylation Contributes to the Counter-Regulatory Response Impairment Following Recurrent Hypoglycemia. PloS ONE 8(7):e68709, 2013. PMCID: PMC3716881.
Cotero, V.E., Zhang, B.B. and V. H. Routh. The response of glucose-excited (GE) neurons in the ventromedial hypothalamus (VMH) to decreased glucose is enhanced in a murine model of type 2 diabetes mellitus (T2DM). J. Neuroendocrinol. 22 (2): 65-74, 2010.
Murphy, B.A., Fakira, K.A., Song, Z., Beuve, A. and V. H. Routh. AMP-activated Protein Kinase (AMPK) and Nitric Oxide (NO) regulate the glucose sensitivity of ventromedial hypothalamic (VMH) glucose-inhibited (GI) neurons. Am. J. Physiology ? Cell. Physiol. 297 (3): C750-758, 2009. PMCID:PMC3496683
Role of hypothalamic glucose sensing neurons in glucose and energy homeostasis