Overview

1986-1994: Department of Genetic Engineering, Korea University in Korea, B. S. including military service
1994-1996: Department of Biological Sciences, KAIST (Korea Advanced Institute of Science and Technology) in Korea, M. S.
1996-1999: Department of Biological Sciences, KAIST in Korea, Ph. D.
1999-2003: Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Baylor College of Medicine, Research Associate
2003-2004: Harvard/Partners Center for Genetics and Genomics, Harvard Medical School, Research Fellow
2004-present: Department of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Assistant Professor

Education

PHD, 1999, KAIST, Dept. of Biological Sciences, Korea
M.S., 1996, KAIST, Dept. of Biological Sciences, Korea
B.S., 1994, Korea University in Korea, Dept. of Genetic Engineering

Curriculum Vitae

View CV

Languages

Korean

Relevant Publications

Yongkyu Park and Mitzi I. Kuroda (2001) Epigenetic aspects of X-chromosome dosage compensation, Science, 293(5532), 1083-1085.

Yongkyu Park, Richard L. Kelley, Hyangyee Oh, Mitzi I. Kuroda, and Victoria H. Meller (2002) Extent of chromatin spreading determined by roX RNA recruitment of MSL proteins, Science, 298(5598), 1620-1623.

Yongkyu Park, G. Mengus, X. Bai, Y. Kageyama, V. H. Meller, P. B. Becker, and M. I. Kuroda (2003) Sequence-specific targeting of Drosophila roX genes by the MSL dosage compensation complex, Mol. Cell, 11(4), 977-986.

Hyangyee Oh, Yongkyu Park, and Mitzi I. Kuroda (2003) Local spreading of MSL complexes from roX genes on the Drosophila X chromosome, Genes & Dev., 17(11), 1334-1339.

Seung-Won Park, Yool Ie Kang, Joanna G. Sypula, Jiyeon Choi, Hyangyee Oh, and Yongkyu Park (2007) An evolutionarily conserved domain of roX2 RNA is sufficient for induction of H4-Lys16 acetylation on the Drosophila X chromosome. Genetics, 177(3), 1429-1437.

Alexander Stark, ??, Yongkyu Park, ?.., and Manolis Kellis (2007) Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature, 450(7167), 219-232.

Seung-Won Park, Mitzi I. Kuroda, and Yongkyu Park (2008) Regulation of histone H4 Lys16 acetylation by predicted alternative secondary structures in roX noncoding RNAs. Mol. Cell. Biol., 28(16), 4952-4962.

Keetae Kim, Yuh-Ru Lin, and Yongkyu Park (2010) Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster. Exp. Gerontol., 45, 984-987. (http://www.ncbi.nlm.nih.gov/pubmed/20849943)

Yuh-Ru Lin, Keetae Kim, Yanfei Yang, Andreas Ivessa, Junichi Sadoshima, and Yongkyu Park (2011) Regulation of longevity by Regulator of G-protein Signaling (RGS) protein, Loco. Aging Cell, 10, 438-447. (http://www.ncbi.nlm.nih.gov/pubmed/21255223)

Yuh-Ru Lin, Hardik Parikh, and Yongkyu Park (2011) Loco signaling pathway in longevity. Small GTPases, 2, 158-161. (http://www.ncbi.nlm.nih.gov/pubmed/21776417)

Course List

CBNP5068Q

Mechanisms of Disease

Regulation of longevity by Imd and Loco signaling pathways in fruitflies

Investigating the mechanisms of the aging process is becoming more important and indispensable to biomedical research due to aging-related human diseases and concerns for public health. In particular, the fruit fly model system, using Drosophila melanogaster, is extremely useful to studying several aspects of the aging process, because both forward and reverse genetic approaches have been shown to be efficient and successful for elucidating the primary physiological aspects of the aging process. Recent investigations of the aging process have shown that several conserved signaling pathways are related to regulation of longevity in various organisms including yeast, worms, flies and mammals. Using D. melanogaster as an aging model system, we are studying longevity mechanisms with Imd and Loco signaling pathways that are known to function in immune response and blood-barrier formation, respectively, and evolutionarily conserved between insect and human.