Overview

CURRENT ACADEMIC APPOINTMENTS
Assistant Professor, 2019 - Present
Department of Pharmacology, Physiology & Neuroscience
New Jersey Medical School, Rutgers University, Newark, NJ


Core Investigator, Brain Health Institute, 2019 - Present
Rutgers University, Piscataway, NJ

Education

PHD, 2007, Baylor College of Medicine
MS, 2001, Korea University, Seoul, Korea
BS, 1995, Korea University

Curriculum Vitae

View CV

Relevant Publications

Arnab Choudhury, Metin Yesiltepe, Tammaryn Lashley, Vishal Singh, Tao Yin, Anllely Fernandez, Luciano D'Adamio, Hyung Jin Ahn (2025). 'Pathological Mechanisms of Motor Dysfunction in Familial Danish Dementia: Insights from a Knock-In Rat Model' Journal of Neuroinflammation, Accepted

Vishal Singh, Arnab Choudhury, Hyung Jin Ahn (2025). 'Fibrinogen's potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer's disease' Neural Regeneration Research 20(1):p 203-204, January 2025. PMID: 39657091.

Vishal Singh, Nicholas Rochakim, Francesca Ferraresso, Arnab Choudhury, Christian J Kastrup, Hyung Jin Ahn (2024). 'Caveolin-1 and Aquaporin-4 as Mediators of Fibrinogen-Driven Cerebrovascular Pathology in Hereditary Cerebral Amyloid Angiopathy' BioRxiv. PMID: 39605467.

Daniel S Gareau, Nicholas RochaKim, Arnab Choudhury, Michael Bamkole, Matija Snuderl, Julia Zou, Anna Yaroslavsky, Steven L Jacques, Sidney Strickland, James G Krueger, Hyung Jin Ahn (2023). 'Fiberoptic hemodynamic spectroscopy reveals abnormal cerebrovascular reactivity in a freely moving mouse model of Alzheimer's disease' Frontier Mol. Neurosci, Volume 16 ' 2023. PMID: 37465366.

Hanna E Berk-Rauch, Arnab Choudhury, Allison T Richards, Pradeep K Singh, Zu-Lin Chen, Erin H Norris, Sidney Strickland, Hyung Jin Ahn (2023). 'Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer's disease' Frontier. Aging Neurosci, Volume 15 ' 2023. PMID: 36967821.

Nicholas M. Tataryn, Vishal Singh, Jonathan P. Dyke, Hanna E. Berk-Rauch, Dana Clausen, Eric Aronowitz, Erin H. Norris, Sidney Strickland, Hyung Jin Ahn (2021) "Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease" Neurobiol. Aging, 107: 96-108

Steven A. Cajamarca, Erin H. Norris, Louise van der Weerd, Sidney Strickland, Hyung Jin Ahn. (2020) "Cerebral amyloid angiopathy-linked beta-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen." Proc. Natl. Acad. Sci, 117: 14482-14492.

Hyung Jin Ahn, Sarah K. Baker, Erin H. Norris, Sidney Strickland (2019) "Inflaming the Brain." Neuron, 101:991-993

Pradeep K. Singh, Masanori Kawasaki, Hanna E. Berk-Rauch, Michael A. Foley, Erin H. Norris, Sidney Strickland, Kazuyoshi Aso, Hyung Jin Ahn (2018) "Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Abeta?Fibrinogen Interaction and Abeta-Induced Contact System Activation." Biochemistry, 57: 1399-1409

Hyung Jin Ahn, Zu-Lin Chen, Daria Zamolodchikov, Erin H. Norris, Sidney Strickland (2017) "Interactions of Beta-Amyloid Peptide with Fibrinogen and Coagulation Factor XII may contribute to Alzheimer's Disease." Curr Opin Hematol, 24: 427-431

Course List

DENT7109Q

Dental Neuroscience

Crosstalk between the cerebrovascular system and the nervous system in Alzheimer's disease

Increasing evidence suggests that cerebrovascular dysfunction is one of the pathological
hallmarks of Alzheimer's disease (AD). Many AD patients suffer from cerebral microinfarcts and
a damaged cerebral vasculature, and a majority of patients with dementia present with both AD
and vascular pathologies. However, the mechanism underlying the vascular contribution in AD is
unclear.
Our lab is interested in the crosstalk between the cerebrovascular system and the nervous
system in AD. To identify molecular targets and biomarkers underlying cerebrovascular deficits
in AD, we are investigating cerebrovascular dysfunction and blood-brain barrier damage in
rodent AD models and postmortem specimens of AD patients using various biochemical &
histochemical techniques, in vivo fiberoptic spectroscopy, in vivo two photon imaging, MRI,
and 3D Immunostaining.