Overview

Dr. William C. Gause received his bachelor?s from the University of Virginia and his Ph.D. at Cornell University (1986). After a postdoctoral fellowship at the National Institutes of Health, Dr. Gause joined the Uniformed Services University of the Health Sciences (USUHS) in Bethesda, MD as a faculty member in the Department of Microbiology and Immunology in 1989. In 2004, Dr. Gause left USUHS and joined the University of Medicine and Dentistry of New Jersey (now Rutgers University) as the Senior Associate Dean for Research, Director of the Center for Immunity and Inflammation, and University Professor of Medicine at New Jersey Medical School. Dr. Gause?s research is internationally recognized and has been continuously funded by the National Institutes of Health since 1991. He has published over 100 papers in the area of infectious disease and inflammation, many in prestigious journals including Nature Medicine, Journal of Experimental Medicine, Nature Reviews Immunology, and Nature Immunology. Dr. Gause has served on numerous NIH study sections, journal editorial boards, given talks and organized and chaired symposia at major national and international scientific meetings, and received a number of awards. His research has recently focused on understanding macrophage function during the type 2 immune response and its role in controlling inflammation and mediating resistance.

Education

PHD, 1986, Cornell University
BA, 1980, University of Virginia

Curriculum Vitae

View CV

Relevant Publications

1. Chen F, Wu W, Millman A, Craft JF, Chen E, Patel N, Boucher JL, Urban JF Jr, Kim CC, Gause WC. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat Immunol. 2014 Oct;15(10):938-46. doi: 10.1038/ni.2984. Epub 2014 Aug 31. PMID: 25173346 [PubMed - in process]

2. Gause WC, Wilson MS. Immunity to parasitic infections at mucous-protected environmental interfaces. Parasite Immunol. 2014 Sep;36(9):397-9. doi: 10.1111/pim.12131. PMID: 25201403 [PubMed - in process]

3. Maizels RM, Gause WC. Immunology. How helminths go viral. Science. 2014 Aug 1;345(6196):517-8. doi: 10.1126/science.1258443. Epub 2014 Jul 31. PMID: 25082688 [PubMed - indexed for MEDLINE]

4. Mishra PK, Palma M, Bleich D, Loke P, Gause WC. Systemic impact of intestinal helminth infections. Mucosal Immunol. 2014 Jul;7(4):753-62. doi: 10.1038/mi.2014.23. Epub 2014 Apr 16. PMID: 24736234 [PubMed - for MEDLINE]

5. Patel N, Wu W, Mishra PK, Chen F, Millman A, Csoka B, Koscso B, Eltzschig HK, Hasko G, Gause WC. A2B adenosine receptor induces protective antihelminth type 2 immune responses. Cell Host Microbe. 2014 Mar 12;15(3):339-50. doi: 10.1016/j.chom.2014.02.001. PMID: 24629340 [PubMed - for MEDLINE]

6. Esser-von Bieren J, Mosconi I, Guiet R, Piersgilli A, Volpe B, Chen F, Gause WC, Seitz A, Verbeek JS, Harris NL. Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Ra-independent alternative differentiation of macrophages. PLoS Pathog. 2013;9(11):e1003771. doi: 10.1371/journal.ppat.1003771. Epub 2013 Nov 14. PMID: 24244174 [PubMed - indexed for MEDLINE]

7. Salgame P, Yap GS, Gause WC. Effect of helminth-induced immunity on infections with microbial pathogens. Nat Immunol. 2013 Nov;14(11):1118-26. doi: 10.1038/ni.2736. Review. PMID: 24145791 [PubMed - indexed for MEDLINE]

8. Mishra PK, Patel N, Wu W, Bleich D, Gause WC. Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response. Mucosal Immunol. 2013 Mar;6(2):297-308. doi: 10.1038/mi.2012.71. Epub 2012 Jul 18. PMID:22806101 [PubMed - indexed for MEDLINE]

9. Chen F, Liu Z, Wu W, Rozo C, Bowdridge S, Millman A, Van Rooijen N, Urban JF Jr, Wynn TA, Gause WC. An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nat Med. 2012 Jan 15;18(2):260-6. doi: 10.1038/nm.2628. PMID: 22245779 [PubMed - indexed for MEDLINE]

10. Mishra PK, Wu W, Rozo C, Hallab NJ, Benevenia J, Gause WC. Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways. J Immunol. 2011 Dec 15;187(12):6491-8. doi: 10.4049/jimmunol.1101392. Epub 2011 Nov 16. PMID: 22095717 [PubMed - indexed for MEDLINE]

Areas Of Interest

interleukin-4

Ag-specific T cell development

Co-stimulatory molecules

Immunology

Infectious Disease; parasitic infections

Pathogenic Mechanisms

Th2-based immune responses

application of imaging technology

interleukin-13

Gause Lab

Metazoan parasites have coevolved with vertebrates over hundreds of millions of years, shaping the activation and function of the immune response including the development of potent immune regulatory pathways and enhanced immune cell-mediated wound healing effects. Understanding the molecular signaling events that trigger this type of immune response can provide insights into new approaches to regulate harmful inflammation and is an important area of Dr. Gause?s research. Research led by Dr. Gause also includes mining the products produced by these parasites for the development of novel therapies to control harmful inflammation and promote tissue repair.