Overview

Education/Training
Sun Yat-sen University of Medical Sciences, China, MD, 1969
Sun Yat-sen University of Medical Sciences, China, MSc, Neuroscience

A. Positions and Honors
Positions and Employment
1983-1993 Assistant-Associate Professor, Department of Physiology, Sun Yat-Sen Univ. Med
Sci
1994-1998 Assistant Professor, Anesthesiology, New Jersey Medical School
1999-2007 Associate Professor, Anesthesiology, New Jersey Medical School
2008-present Professor, Anesthesiology, New Jersey Med School

Other Experience and Professional Memberships
Current Editorial Boards ?
1) Int J Physiol Pathophysiol Pharmacol (IJPPP)
2) The Open Journal of Neuroscience
Ad hoc reviewer for 46 American and international journals

Education

MS, 1981, Sun Yat-Sen University Medical Sciences, China
MD, 1969, Sun Yat-Sen University Medical Sciences, China

Languages

Chinese

Relevant Publications

Liu YW, Li J, Ye JH. Histamine regulates activities of neurons in the ventrolateral preoptic nucleus. J Physiol. 2010;588(Pt 21):4103-16.

Guan YZ, Ye JH. Ethanol blocks long-term potentiation of GABAergic synapses in the ventral tegmental area involving mu-opioid receptors. Neuropsychopharmacology. 2010;35(9):1841-9.

Nguyen HT, Li KY, daGraca RL, Delphin E, Xiong M, Ye JH. Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors. Anesthesiology. 2009;110(2):326-32.

Deng C, Li KY, Zhou C, Ye JH. Ethanol enhances glutamate transmission by retrograde dopamine signaling in a postsynaptic neuron/synaptic bouton preparation from the ventral tegmental area. Neuropsychopharmacology. 2009 ;34(5):1233-44.

Xiao C, Shao XM, Olive MF, Griffin WC 3rd, Li KY, Krnjevic K, Zhou C, Ye JH. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology. 2009;34(2):307-18.

Ye JH*, Wang F, Krnjevic K, Wang W, Xiong ZG, Zhang J. Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area. J Neurosci. 24(41):8961-74, 2004.

Wang FS, Xiao C, Ye JH*. Taurine activates excitatory non-synaptic glycine receptors on dopaminergic neurons in ventral tegmental area of young rats. J. Physiology, 565:503-516, 2005 Ye JH*, Zhang J, Xiao C, Kong JQ. Patch clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: glycerol replacement of NaCl protects CNS neurons. J. Neurosci Methods, 158:251-259, 2006.

Ye JH*, Tao L, Ren J, Schaefer R, Krnjevic K, Liu PL, Schiller DA, McArdle JJ. Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area. J. Pharmacol. Exp. Ther. 296(1):77-83, 2001.

Xiao C, Zhang J, Krnjevic K, Ye JH*. Effects of ethanol on midbrain neurons: Role of opioid receptors. Alcoholism: Clin Exp Res. 31(7):1106-1113, 2007.

Xiao C, Ye JH*. Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: role of ?-opioid receptors. Neuroscience, 153(1):240-8, 2008.

Areas Of Interest

glutamate

GABA

Neuroscience

alcohol addiction

dopamine

general anesthetics

glycine

midbrain

patch-clamp electrophysiology

ventral tegmental area

The role of the lateral habenula (LHb) in alcohol addiction

The laboratory is engaged in research in two areas: 1. Mechanisms of alcohol addiction. 2. Mechanisms of general anesthetics. In addition to the fact that alcohol is a general anesthetic, these two research areas are related in terms of many of the techniques used, which include: electrophysiological recordings in brain slices and isolated neurons, morphological immunocytochemistry and behavioral approaches.

Our work on alcohol addiction is directed towards understanding the mechanisms by which ethanol increase the excitability of dopaminergic neurons. The laboratory is particularly interested in the role of the GABAergic and glutamatergic inputs to the dopaminergic neurons of the ventral tegmental area; a brain region mediates the rewarding effects of abused drugs including alcohol. Additionally, we are interested in the mechanisms underlying the adaptation changes in the mesolimbic circuitries induced by chronic alcohol (drug) exposure.

Our work on general anesthetics is directed towards understanding the mechanisms by which anesthetics induce sedation. There is recent evidence that the sedative effects of general anesthetics are associated with the endogenous sleep pathways. Our works focus on the ventral lateral preoptic area (VLPO).