NJMS-UH Cancer Center (NJMSUHCC) 205 South Orange Avenue Room G-1218 Newark, NJ 07101 Phone: (973) 972-5394
George Yap obtained his BS and MS degrees from the University of the Philippines and his PhD from McGill University in Montreal, under the
supervision of Dr. Mary M. Stevenson. In 1994, he joined the Immunobiology Section of the Laboratory of Parasitic Diseases, National Institutes
of Allergy and Infectious Diseases of the NIH in Bethesda MD and worked under the supervision of Dr. Allen Cheever and Dr. Alan Sher. At NIH,
he dissected the roles of IL-12, IFN-gamma and TNF-alpha in the host immune response to Toxoplasma gondii. This work led to an appreciation
for the role of IL-12 in the maintenance of Th1 immunity and for the role of iNOS-independent mechanisms of cell-autonomous resistance of
hemopoietic and parenchymal tissue cells to intracellular parasitism. In 2000, Dr. Yap joined the Department of Molecular Microbiology and
Immunology at Brown University in Providence Rhode Island, where the taught immunology to Brown undergraduates and established his
independent research laboratory. His laboratory discovered Tyk2 as a genetic determinant of disease susceptiblity and identified a novel
mechanism for intracellular killing of the parasite Toxoplasma gondii. In 2007, Dr. Yap joined the Center for Immunity and Inflammation at NJMS
where he continues his research on T cell and innate immune responses to Toxoplasma gondii. He has served as a Regular Member of Innate
Immunity and Inflammation Study Section of the NIH.
Ph.D., 1994, McGill University M.S., 1989, University of the Philippines B.S., 1987, University of the Philippines
Shaw, M., Boyartchuk, V. , Wong, S., Kashioghoff, M. Ragimbeau, J, Pellegrini, S., Muller, M., Dietrich, W., and Yap, G. S..
2003. A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to
infectious and autoimmune disease. Proceedings of the National Academy of Sciences 100:11594-11599.
Ling, Y., Shaw, M., Ayala, C., Coppens, I., Taylor, G.A., Ferguson, D and G.S. Yap. 2006. Vacuolar and plasma
stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. Journal of Experimental
G.S. Yap, Y. Ling, and Y. Zhao. 2007. Autophagic elimination of intracellular parasites: convergent induction by IFN-?
and CD40 ligation? Autophagy. 3:163-165.
Yap, G. S. and A. Iwasaki. 2008. Securing mucosal borders: migrant monocytes to the rescue. Cell Host and Microbe
Wilson, D.C., S. Matthews and G.S. Yap. 2008. IL-12 signaling drives CD8+ T cell IFN-gamma production and
differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii infection. Journal of Immunology
Zhao, Y., D.J.P. Ferguson, D.C. Wilson, J.C. Howard, L.D. Sibley, and G.S. Yap. 2009. Virulent Toxoplasma gondii evade
immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. Journal of Immunology
Wilson, D.C., Grotenbreg, G.M., Liu, K., Zhao, Y., Frickel, E.M., Gubbels, M.J., Ploegh, H.L. and G.S. Yap. 2010.
Differential regulation of effector and central memory responses to Toxoplasma gondii infection by IL-12 revealed by
tracking of Tgd057-specific CD8+ T cells. Public Library of Science Pathogens 19;6(3):e1000815.
Zhao, Y., Marple, A., Ferguson, D., Bzik, D., and G.S. Yap. 2014. Avirulent strains of Toxoplasma gondii invade
macrophages by active invasion from the phagosome. Proceedings of the National Academy of Sciences 111:6437-
Shah, S, Grotenbreg. G, Rivera, A and G. S. Yap. 2015. An extrafollicular pathway for the generation of effector CD8 T
cells driven by the proinflammatory cytokine IL-12. Elife. 2015 Aug 5;4. doi: 10.7554/eLife.09017
Marple, A., Wu, W., Shah, S., Zhao, Y. Du, P., Gause, W., and G. S. Yap. 2017. Cutting edge: Helminth coinfection
blocks effector differentiation of CD8 T cells through alternate host Th2 and IL-10-mediated responses. Journal of