Overview

Lab Members

Teresa (Terri) L. Wood, PhD
Email: terri.wood@rutgers.edu

Research: The Wood laboratory is focused on determining how growth factors and signaling
pathways interact to promote growth, survival and differentiation of breast epithelial and
neural progenitor cells. We conduct in vitro and in vivo studies and make use of mouse
models carrying genetic alterations in genes of interest, particularly in the insulin-like
growth factor family of ligands and receptors and in the TSC/mTOR signaling pathway. These
studies are designed to reveal normal functions of these signaling pathways in growth and
development as well as in neurological disorders and in dysregulated growth in cancer cells.

Quan Shang, Research Associate
shangqu@njms.rutgers.edu

Krystopher Maingrette, Grad Student
Email: km1136@gsbs.rutgers.edu

Divyangi Kantak, Grad Student
Email: dkk53@gsbs.rutgers.edu

Mimi Mather, Grad Student
Email: mlm497@gsbs.rutgers.edu

Christopher Galifi, MD/PhD Student
Email: cag330@njms.rutgers.edu

Education

PHD, 1987, University of California, Los Angeles
B.A., 1978, Carleton College, Minnesota

Curriculum Vitae

View CV

Relevant Publications

Obr, A.E., Chang, Y.-J., Ciliento, V., Maingrette, K., Bulatowicz, J., LeMenze, A., Shang, Q., Gallagher, E., LeRoith, D. and Wood, T.L. (2022) Breast tumor IGF-1R regulates cell-cell adhesion and metastasis: Alignment of mouse single cell and human breast cancer transcriptomics. Frontiers in Oncology, ResearchTopic 'Women in Breast Cancer Vol. II: 2022' (in press).

Khandker, L., Jeffries, M.A., Chang, Y.-J., Mather, M.L., Evangelou, A.V., Bourne, J.N., Tafreshi, A.K., Ornelas, I.M., Bozdagi-Gunal, O., Macklin, W.B. and Wood, T.L. (2022) Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord. Cell Reports 38(9):110423. DOI:https://doi.org/10.1016/j.celrep.2022.110423

Chidambaram, S., Rothbard, D., Cajuste, Y., Deshpande, K. Snyder, K., Fajardo, E. Fiser, A., Tapinos, N., Levison, S.W.*, and Wood, T.L.* (2022) Insulin receptor is essential for the self-renewal of adult neural stem cells and glioblastoma stem cells. *Co-senior authors. Stem Cell Reports Apr 25:S2213-6711(22)00196-5. doi: 10.1016/j.stemcr.2022.04.007.

Bernadais, K.*, Ornelas, I.M.*, Fauveau, M.*, Brown, T.L., Debous, C, Macklin, W.B., Wood, T.L.# and Nait-Oumesmar, B.# (2022) p70S6 kinase is active during oligodendrocyte development and in demyelinated lesions and promotes oligodendrocyte differentiation. Brain Communications 4(1):fcac025. DOI: 10.1093/braincomms/fcac025 *equal contributions; #Co-senior authors PMID:35224490

Jeffries, M.A., McLane, L.E., Khandker, L., Mather, M.L., Evangelou, A.V., Kantak, D., Bourne, J.N., Macklin, W.B. and Wood, T.L. (2021) mTOR signaling regulates metabolic function in oligodendrocyte precursor cells and promotes efficient brain remyelination in the cuprizone model. J. Neuroscience, Early Release, 20 August 2021, JN-RM-1377-20; DOI: https://doi.org/10.1523/JNEUROSCI. 1377-20.2021

Jeffries, M.A., Obr, A.E., Urbanek, K.L., Fyffe-Maricich, S.L. and Wood, T.L. (2020) Cnp promoter-driven sustained ERK1/2 activation increases B-cell activation and suppresses experimental autoimmune encephalomyelitis. ASN Neuro Published online 2020 Nov 23. doi: 10.1177/1759091420971916.

Musah, A.S., Brown, T.L., Jeffries, M., Shang, Q., Hashimoto, H., Evangelou, A.V., Kowalski, A., Batish, M., Macklin, W.B. and Wood, T.L. (2020) Mechanistic target of rapamycin regulates the oligodendrocyte cytoskeleton during myelination. J. Neuroscience 40:2993-3007

Ornelas, I.M.O.*, Khandker, L.*, Wahl, S.E., Hashimoto, H., Macklin, W.B. and Wood, T.L. (2020) The mTOR pathway downregulates BMP signaling to promote oligodendrocyte differentiation. GLIA 68:1274-1290. *equal contributions

Ziegler, A.N.#, Feng, Q.#, Chidambaram, S., Testai, J.M., Kumari, E., Rothbard, D.E., Constancia, M., Sandovici, I., Cominski, T., Pang, K., Gao, N. Wood, T.L.* and Levison, S.W.* (2019) Insulin-like growth factor II: An essential adult stem cell niche constituent in brain and intestine. Stem Cell Reports 12:816-830. #co-first authors; *co-senior authors

Obr, A.E., Kumar, S., Chang, Y.J., Bulatowicz, J.J., Barnes, B.J., Birge, R.B., Lazzarino, D.A., Gallagher, E., LeRoith, D. and Wood, T.L. (2018) Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment. Breast Cancer Res. Nov 20;20(1):138. doi: 10.1186/s13058-018-1063-2.

Areas Of Interest

Cancer

Cancer Oncology

Cellular Signal Transduction

Differentiation

Growth Factors

Molecular Mechanisms of Tumor Growth and Metastasis

Multiple Sclerosis

Neuroscience

Oligodendrocyte Proliferation

Stem / Progenitor Cells

Survival

Course List

CBNP5150Q		Cell/Dev. Neuroscience
GSND5006Q		Grantsmanship Skills
GSND5200Q		Intro to Biomedical Sciences
MBGC5015Q		Cancer Biology: Extrinsic