Overview

Dr. Suzuki received her Ph.D. from the Johns Hopkins University conducting her thesis research with Richard D. Klausner, M.D. at the National Institutes of Health, USA where she studied protein quality control mechanisms in the endoplasmic reticulum and secretory pathway that ensure the T-cell antigen receptor complex is properly assembled and expressed on the plasma membrane of cells. She was a post-doctoral fellow with Gottfried Schatz, Ph.D. at the Biozentrum at the University of Basel, Switzerland where she embarked on studies focusing on the function of ATP-dependent proteases and chaperones ans their importance in mitochondrial biogenesis and proteostasis. Since joining New Jersey Medical School, the Suzuki Lab has contributed to understanding the impact of the mitochondrial ATP-dependent protease LONP1 in mitochondrial energy metabolism, proteostasis, and disease pathogenesis. Her lab explores interorganellar cell stress responses and their effect on metabolic rewiring, mitochondrial gene expression, proteostasis, and disease pathogenesis.

Education

BSC, 1984, University of Illinois at Urbana, Biological Sciences
PHD, 1992, Johns Hopkins University, Cell Biology

Curriculum Vitae

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Relevant Publications

Shetty, R., Noland, R., Nandi, G. & Suzuki, C.K. Powering down the mitochondrial LonP1 protease: a novel strategy for anticancer therapeutics. Expert Opin Ther Targets, Expert Opin Ther Targets, 28:9-15 (2024).

Lee, J., Pandey, A. K., Venkatesh, S., Thilagavathi, J., Honda, T., Singh, K., Suzuki, C.K. Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP - binding and -hydrolysis via CDDO and its derivatives. J. Biol. Chem. 298:101719 (2022).

Li, S., Li, W., Yuan, J., Bullova, P., Wu, J., Zhang, X., Liu, Y., Plescher, M., Rodriguez, J., Bedoya-Reina, O. C., Jannig, P. R., Valente-Silva, P., Yu, Meng, A. Henriksson, M., Zubarev, R. A., S??rensen, A. S., Suzuki, C. K., Ruas, J. L., Holmberg, J., Larsson, C., Juhlin, C. C., von Kriegsheim, A., Cao, Y., Schlisio, S. Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome. Nature Metabolism 4:739 (2022)

Nimmo, G.A.M., Venkatesh, S., Pandey, A.K., Marshall, C.R., Hazrati, L.Z., Blaser, S., Ahmed, S., Cameron, J., Singh, K., Ray, P.N., Suzuki, C.K, Yoon, G.* Bi-allelic mutations of LONP1 encoding the mitochondrial LonP1 protease cause pyruvate dehydrogenase deficiency and profound neurodegeneration with progressive cerebellar atrophy. Hum. Mol. Gen., 28:290 (2019) **Co-Corresponding Authors

Venkatesh, S., Li, M., Saito, T., Rashed, E., Mareedu, S., Zhai, P., Barcena, C., Lopez-Otin, C., Yehia, G., Sadoshima, G., Suzuki, C.K. Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo. J. Mol. Cell, Cardio., 128:38 (2019).

King, G.A., Shabestari, M.H., Taris, K.H., Pandey, A.K., Venkatesh, S., Thilagavathi, T., Singh, K., Koppisetti, R.K., Temiakov, D., Roos, W.H., Suzuki, C.K., Wuite, G.J.L., Acetylation and phosphorylation of human TFAM provide contrasting mechanisms for regulating non-specific TFAM-DNA interactions. Nucleic Acids Research, 46(7): 3633'3642 (2018)

Strauss, K.A., Jinks, R.N., Puffenberger, E.G. Venkatesh, S., Singh, K., Cheng, I., Mikita, N., Thilagavathi, J., Lee, J., Sarafianos, S., Benkert, A., Koehler, A., Zhu, A., Trovillion.V., McGlincy, M., Morlet, T., Deardorff, M., Innes, A.M., Prasad, C., Chudley, A.E., Lee, I.N.W., and Suzuki, C.K. CODAS syndrome is associated with mutations of LONP1 encoding mitochondrial AAA+ Lon protease. Am. J. Hum. Genet. . 96, 121?135 (2015).

Lu B, Lee J, Nie X, Li M, Morozov YI, Venkatesh S, Bogenhagen DF, Temiakov D, Suzuki CK. Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. Molecular Cell, 49:121 (2013).

Bernstein, S.H., Venkatesh, S. Li, M., Lee, J., Lu B., Hilchey, S.P., Morse, K.M., Metcalf, H.M., Andreeff, M., Brookes, P.S. and Suzuki, C.K., The mitochondrial ATP-dependent Lon protease: a novel drug target in lymphoma death mediated by the synthetic triterpenoids CDDO and its derivatives. Blood. 119:3321 (2012).

Chen S.H., C.K. Suzuki and S.H. Wu, Thermodynamic Characterization of Specific Interactions between Human Lon Protease and G-quartet DNA. Nucl. Acids Res. 36:1273 (2008).

Course List

16356611Q

Grad ELL Writing Studio

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