Dr. Hreday N. Sapru has an outstanding record in research, teaching and other academic activities. He received MS and Ph.D. degrees in Pharmaceutics from Banaras University, India. In 1967, he received a Fulbright Scholarship for further studies in the USA. He received MS, M. Phil and Ph.D. degrees in Pharmacology from Columbia University, New York and was awarded a distinction for his Ph.D. thesis work. In 1974, Dr. Sapru was appointed as an Instructor in the Department of Neurological Surgery, Rutgers New Jersey Medical School (RNJMS) where he rose through the ranks to the tenured position of Professor, a position he held until his retirement in December 2018. Dr. Sapru also held a joint appointment in the Department of Pharmacology, Physiology and Neuroscience. He was invited as a Visiting Professor and seminar or symposium speaker by different national and international institutions. He was awarded Exceptional Merit Award by RNJMS in 1983. He is a Fellow of the Cardiovascular Section, American Physiological Society. At the National Institutes of Health (NIH), he served as a regular member in Hypertension and Microcirculation study section (2006-2010) and as Chairman or member of several special emphasis panels. He is on the Editorial Boards of several national scientific journals. He was continuously funded for 35 years by NIH as Principal Investigator on two simultaneous R01 grants. He was involved in didactic teaching of medical, dental and graduate students.
Ph.D., 1974, Columbia University
1. Kawabe T, V. C. Chitravanshi, K. Kawabe and H. N. Sapru. Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius, Neuroscience, 153: 605-617, 2008 (highlighted in Faculty of 1000 which identifies and evaluates the most important articles in biology and medical research).
2. Nakamura, T., Kazumi Kawabe, and Hreday N. Sapru. Cardiovascular responses to microinjections of urocortin 3 in the nucleus tractus solitarius of the rat. Am. J. Physiol. 296: H325-H332, 2009 (highlighted in Faculty of 1000) .
3. Nakamura, T., Bhatt, S. and Sapru HN. Cardiovascular responses to hypothalamic arcuate nucleus stimulation in the rat: Role of sympathetic and vagal efferents. Hypertension, 54: 1369- 1375, 2009 (highlighted in Faculty of 1000).
4. Chitravanshi VC, Sapru HN. Cardiovascular responses elicited by a new endogenous angiotensin in the nucleus tractus solitarius of the rat. Am. J. Physiol-Heart and Circ. Physiol. 300:H230-H240, 2011.
5. Arakawa H, Chitravanshi VC, Sapru HN. Hypothalamic arcuate nucleus: a new site of cardiovascular action of angiotensin-(1-12) and angiotensin II. Am. J. Physiol-Heart and Circ. Physiol. 300:H951?H960, 2011.
6. Kawabe T, Kawabe K, Sapru HN Cardiovascular Responses to Chemical Stimulation of the Hypothalamic arcuate nucleus in the rat: Role of the hypothalamic paraventricular nucleus. Plos One, in press, 2012.
Areas Of Interest
Central control of cardiovascular function in health and disease
Dr. Sapru has been conducting research in ?Central control of cardiovascular function? for past 38 years. Some of the seminal observations reported first from this laboratory include: identification of the ventrolateral medullary pressor and depressor areas which are crucial in regulating cardiovascular function, unraveling pathways connecting different cardiovascular brain areas, determination of the role of different neurotransmitters and neuromodulators in these pathways and identification of abnormal function of these pathways in cardiovascular diseases such as hypertension. Currently investigations are in progress to elucidate the role of hypothalamic arcuate nucleus in cardiovascular function in health and disease.