Rutgers New Jersey Medical School

Department of Medicine

Hassan Safi, PHD

Assistant Professor-Research

Department of Medicine
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Overview

Dr. Safi obtained his PhD in Biological sciences from the University of Seville, Spain. His doctoral dissertation titled ?Molecular epidemiology of Mycobacterium tuberculosis in Seville, Spain?. He then spent 1 year at the University of Arkansas for Medical Sciences as postdoctoral fellow, where he initiated his research interests on Mycobacterium tuberculosis drug resistance. His second postdoctoral position was at the University of Texas Health Center, where he was trained in the immunology of Mycobacterium tuberculosis infection. Dr. Safi joined NJMS in 2004. His research emphasizes the use of Next Generation Sequencing and microbiology to elucidate novel mechanisms of evolution and dynamics of antimicrobial tolerance in M. tuberculosis.

Education

PHD, 1999, University of Seville, Sevilla, Spain

Curriculum Vitae

View CV

Languages

Arabic
French
Spanish

Relevant Publications

Safi H, Lingaraju S, Amin A, Kim S, Jones M, Holmes M, McNeil M, Peterson S, Chatterjee D, Fleischmann R, and Alland D. Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-?-D-arabinose biosynthetic and utilization pathway genes. Nat Genet. 2013 Oct; 45(10):1190-7. doi: 10.1038/ng.2743. Epub 2013 Sep 1.

Helb D, Jones M, Story E, Boehme C, Wallace E, Ho K, Kop J, Owens MR, Rodgers R, Banada P, Safi H, Blakemore R, Lan NT, Jones-Lopez EC, Levi M, Burday M, Ayakaka I, Mugerwa RD, McMillan B, Winn-Deen E, Christel L, Dailey P, Perkins MD, Persing DH, and Alland D. Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near- patient technology. J Clin Microbiol. 2010 Jan; 48(1):229-37.

Safi H, Fleischmann RD, Peterson SN, Jones MB, Jarrahi B, and Alland D. Allelic exchange and mutant selection demonstrate that common clinical embCAB gene mutations only modestly increase resistance to ethambutol in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2010 Jan; 54(1):103-8

Chakravorty S, Aladegbami B, Motiwala AS, Dai Y, Safi H, Brimacombe M, Helb D, and Alland D. Rifampin resistance, Beijing-W clade-single nucleotide polymorphism cluster group 2 phylogeny, and the Rv2629 191-C allele in Mycobacterium tuberculosis strains. J Clin Microbiol 2008 Aug; 46(8):2555-60.

Safi H, Sayers B, Hazbon MH, and Alland D. Transfer of embB codon 306 mutations into clinical Mycobacterium tuberculosis strains alters susceptibility to ethambutol, isoniazid, and rifampin. Antimicrob Agents Chemother 2008 Jun;52(6):2027-34.

Colangeli R, Helb D, Vilcheze C, Hazbon MH, Lee CG, Safi H, Sayers B, Sardone I, Jones MB, Fleischmann RD, Peterson SN, Jacobs WR Jr, and Alland D. Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis. PLoS Pathog 2007Jun;3(6):e87.

Vankayalapati R, Garg A, Porgador A, Griffith DE, Klucar P, Safi H, Girard WM, Cosman D, Spies T, and Barnes PF. Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacterium. J. Immunol. 2005 Oct 1;175(7):4611-7.

Samten B, Howard ST, Weis SE, Wu S, Shams H, Townsend JC, Safi H, and Barnes PF. Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen. J. Immunol, 2005, 174(10): 6357-6363.

Safi H, Barnes PF, Lakey DL, Shams H, Samten B, Vankayalapati R, and Howard ST. IS6110 functions as a mobile, moncyte-activated promoter in Mycobacterium tuberculosis. Mol. Microbiol. 2004; 52(4): 999-1012.

Safi H, Gormus BJ, Didier PJ, Blanchard JL, Lakey DL, Martin LN, Murphy-Corb M, Vankayalapati R, and Barnes PF. Spectrum of Manifestations of Mycobacterium tuberculosis Infection in Primates Infected with SIV. AIDS Res. Hum. Retroviruses 2003; 19(7): 585-595.