Medical Science Building (MSB) 185 South Orange Avenue Room I617 Newark, NJ 07101 Phone: (973) 972-8869
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Overview
Dr. Shirokov joined NJMS in 2000 after post-doctoral studies at Rush-Presbyterian-St.Luke's Medical
Center in Chicago. Dr. Shirokov has trained 5 postdocs, 4 PhD, and 2 Master thesis students. He teaches
in Molecular Physiology of Cell Communication course of the School of Graduate Studies and directs a
team-taught Dental Physiology course of the Rutgers School of Dental Medicine. Dr. Shirokov has
authored 21 peer-reviewed research articles and a book chapter. He heads the Section of Medicine and
Biology and is an Academic Vice President of the Shevchenko Scientific Society.
Education
PHD, 1989, Bogomoletz Institute of Physiology M.S., 1989, Moscow Institute of Physics & Technology, Russia B.S., 1983, Moscow Institute of Physics & Technology, Russia
Relevant Publications
Ulyanova, A.V., and Shirokov R.E.; Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles. PLoS ONE 13(4): e0194980, 2018
Shirokov R.; What's in gating currents? Going beyond the voltage sensor movement; Biophysical Journal, 101(2): 512-514, 2011
Course List
Molecular physiology and genetics of voltage-gated ion channels
Current research focuses on understanding molecular principles of sensing transmembrane voltage by ion channels. Research techniques include: measurement of ionic and intramembrane charge movements, structure-function analysis of various sodium and calcium channels in various tissues and in heterological systems. Significant effort is devoted to development of novel algorithms of multiple sequence alignment and molecular phylogeny. These are applied to predict and analyze effects of site-directed mutations and naturally occuring variants.
