Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A.
Lee BH, De Jesus Perez JJ, Moiseenkova-Bell V, Rohacs T.
Nature Communications 2023 Sep 21;14(1):5883. |
| Su S, Yudin Y, Kim N, Tao YX, Rohacs T.
TRPM3 Channels Play Roles in Heat Hypersensitivity and Spontaneous Pain after Nerve
Injury.
J Neurosci. 2021 Mar 17;41(11):2457-2474. |
| Zhao, S., Yudin, Y., and Rohacs, T. (2020). Disease-associated mutations in the human
TRPM3 render the channel overactive via two distinct mechanisms. eLife 9, e55634. |
| Del Rosario, J.S., Yudin, Y., Su, S., Hartle, C.M., Mirshahi, T., and Rohacs, T. (2020). Gi-
coupled receptor
activation potentiates Piezo2 currents via Gbetagamma. EMBO Reports 21, e49124. |
| Hughes, T. E.*, Del Rosario, J. S.*, Kapoor, A.*, Yazici, A. T., Yudin, Y., Fluck, E. C.,
Filizola, M.#, Rohacs,
T.#, and Moiseenkova-Bell, V. Y.# (2019) Structure-based characterization of novel
TRPV5 inhibitors. eLife
(2019) 8 pii: e49572 *contributed equally #co-corresponding authors |
| Yudin Y, Rohacs T. The G protein-biased agents PZM21 and TRV130 are partial agonists
of mu-opioid
receptor-mediated signaling to ion channels. Br J Pharmacol. (2019) 176(17):3110-3125 |
| Hughes, T.E.T., Pumroy, R.A., Yazici, A.T., Kasimova, M.A., Fluck, E.C., Huynh, K.W.,
Samanta, A., Mulugu, S.K., Zhou, Z.H., Carnevale, V., Rohacs,T., Moiseenkova-
Bell,V.Y.: Structural insights on TRPV5 gating by endogenous modulators, Nature
Communications, (2018) 9(1):4198 |
| Badheka, D., Yudin, Y., Borbiro, I., Hartle, C.M., Yazici, A., Mirshahi, T., Rohacs, T.:
Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein beta-
gamma subunits, eLife 2017, 6. pii: e26147 |
| Elokely, K., Velisetty, P., Delemotte, L., Palovcak., E, Klein, M.L., Rohacs, T.,
Carnevale. V. Understanding TRPV1 activation by ligands: Insights from the binding
modes of capsaicin and resiniferatoxin. Proc Natl Acad Sci U S A. 2016; 113(2):E137-45 |
| Borbiro, I., Badheka, D., Rohacs, T.: Activation of TRPV1 inhibits piezo channels via
phosphoinositide depletion, Science Signaling, 2015, 8, ra15 |
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