Zhao, S., Yudin, Y., and Rohacs, T. (2020). Disease-associated mutations in the human TRPM3 render the channel
overactive via two distinct mechanisms. eLife 9, e55634. |
| Del Rosario, J.S., Yudin, Y., Su, S., Hartle, C.M., Mirshahi, T., and Rohacs, T. (2020). Gi-coupled receptor activation
potentiates Piezo2 currents via Gbetagamma. EMBO Rep 21, e49124. |
| Hughes, T. E.*, Del Rosario, J. S.*, Kapoor, A.*, Yazici, A. T., Yudin, Y., Fluck, E. C., Filizola, M.#, Rohacs, T.#, and
Moiseenkova-Bell, V. Y.# (2019) Structure-based characterization of novel TRPV5 inhibitors. eLife (2019) 8 pii: e49572
*contributed equally #co-corresponding authors |
| Yudin Y, Rohacs T. The G protein-biased agents PZM21 and TRV130 are partial agonists of mu-opioid receptor-mediated
signaling to ion channels. Br J Pharmacol. (2019) 176(17):3110-3125 |
| Hughes, T.E.T., Pumroy, R.A., Yazici, A.T., Kasimova, M.A., Fluck, E.C., Huynh, K.W., Samanta, A., Mulugu, S.K., Zhou,
Z.H., Carnevale, V., Rohacs,T., Moiseenkova-Bell,V.Y.: Structural insights on TRPV5 gating by endogenous modulators,
Nature Communications, (2018) 9(1):4198 |
| Hughes, T.E.T., Lodowski, D.T., Huynh, K.W., Yazici, A., Del Rosario, J., Kapoor, A., Basak, S., Samanta, A., Han, X.,
Chakrapani, S., Zhou, Z.H., Filizola, M., Rohacs, T., Han, S., and Moiseenkova-Bell, V.Y. (2018). Structural basis of TRPV5
channel inhibition by econazole revealed by cryo-EM. Nat Struct Mol Biol 25, 53-60. |
| Badheka, D., Yudin, Y., Borbiro, I., Hartle, C.M., Yazici, A., Mirshahi, T., Rohacs, T.:
Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein beta-gamma
subunits, eLife 2017, 6. pii: e26147 |
| Carnevale V, Rohacs T. TRPV1: A Target for Rational Drug Design. Pharmaceuticals
(Basel). 2016 Aug 23;9(3) |
| Elokely, K., Velisetty, P., Delemotte, L., Palovcak., E, Klein, M.L., Rohacs, T.,
Carnevale. V. Understanding TRPV1 activation by ligands: Insights from the binding modes
of capsaicin and resiniferatoxin. Proc Natl Acad Sci U S A. 2016; 113(2):E137-45 |
| Borbiro, I., Badheka, D., Rohacs, T.: Activation of TRPV1 inhibits piezo channels via
phosphoinositide depletion, Science Signaling, 2015, 8, ra15 |
|