Ozlem Bozdagi Gunal, MD, PhD is an Assistant Professor of Psychiatry at the Rutgers New Jersey Medical School. She received her MD, and PhD in Pharmacology from Hacettepe University in Turkey. She completed her post-doctoral studies at Duke University, and at the Icahn School of Medicine at Mount Sinai, Department of Neuroscience. Dr. Gunal has previously held faculty position at the Icahn School of Medicine at Mount Sinai, Department of Psychiatry. Dr. Gunal?s work identifies the molecular mechanisms affecting neuronal function and plasticity in rodent models of neuropsychiatric disorders, including autism, intellectual disability, and addiction behavior. Her laboratory efforts combine electrophysiology, molecular biology, biochemistry, pharmacology, neuronal morphology, and behavioral characterization to translate basic neurobiology findings into effective treatments. A major line of investigation in the lab focuses on understanding the mechanisms by which cytoplasmic FMRP interacting protein 1 (Cyfip1) regulates synapse function and plasticity in developing neural circuits, and how the changes in Cyfip1 levels lead to several neuropsychiatric brain disorders. Dr. Gunal?s research is supported through grants from several foundations and the National Institute of Mental Health.
Kajiwara Y., McKenzie A., Dorr N., Gama Sosa M.A., Elder G., Schmeidler J.,
Dickstein D.L., Bozdagi O., Zhang B., Buxbaum J.D. The human-specific CASP4
gene product contributes to Alzheimer-related synaptic and behavioural deficits.
Hum Mol Genet. 2016 Aug 11. PMID: 27516385
Hsiao K., Nicolas-Harony H., Buxbaum J.D., Bozdagi-Gunal O.*, Benson D.*;
Cyfip1 regulates presynaptic function during development via WAVE1. Journal of
Neuroscience February 3; 36(5):1564 ?1576 (2016).
Hsiao, K., Bozdagi, O. and Benson, D. Cap-dependent translation regulates
presynaptic P35. Developmental Neurobiology. Nov 19 (2014) PMID: 24254883
Bozdagi, O., Tavassoli, T., Buxbaum, J.D. Insulin-like growth factor-1 rescues
synaptic and motor deficits in a mouse model of autism and developmental delay.
Molecular Autism. Apr 27;4(1):9 (2013) PMID: 23621888
Arguello, A.A., Bozdagi, O., Pollonini G., Tronel S., Bambah-Mukku D., Huntley,
G. W., Platano D., Alberini, C. M. CCAAT enhancer binding protein delta in the
hippocampus and amygdala plays an essential role in memory consolidation. Journal
of Neuroscience, Feb 20;33(8):3646-58 (2013)
Bozdagi, O., Sakurai, T., Dorr, N., Pilorge, M., Takahashi, N., Buxbaum, J.D.
Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS One;
7(8): e42422 (2012)
Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D.L., Takahashi, N.,
Kajiwara, Y., Yang, M., Katz, A.M., Scattoni, M.L., Harris, M.J., Saxena, R.,
Silverman, J.L., Crawley, J.N., Zhou, Q., Hof, P.R., Buxbaum, J.D.
Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic
function, social interaction, and social communication. Molecular Autism. Dec
17;1(1):15 (2010) PMID: 21167025
Nagy, V.*, Bozdagi, O.*, Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J.,
Costa, R. M., Silva, A. J., Kaczmarek, L., and Huntley, G. W. Matrix
Metalloproteinase-9 Is Required for Hippocampal Late-Phase Long-Term
Potentiation and Memory. Journal of Neuroscience, 26(7):1923?1934 (2006) PMID:
Bozdagi, O., Shan,W. S., Tanaka, H., Benson, D.L. and Huntley, G.W. Increasing
numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized,
recruited to synaptic sites and required for potentiation. Neuron, 28: 245?259 (2000)