International Center for Public Health (ICPH) 225 Warren Street Room E450U
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Overview
Dr. Neiditch completed his undergraduate education in 1996 at Rutgers University in New Brunswick with a
bachelor's degree in Biological Sciences. As an undergraduate student, Dr. Neiditch studied non-nutritive
sweeteners and nutraceuticals at Johnson & Johnson, Inc., and concluded this research as a postgraduate
student in 1997.
Dr. Neiditch earned his Ph.D. in 2002 from Baylor College of Medicine, where he studied the molecular
mechanisms of VDJ recombination. This cellular process generates T-cell receptors, B-cell receptors, and
antibodies. During this work, he discovered a reaction responsible for genomic instability in lymphocytes,
publishing in Cell; Molecular Cell; and Molecular and Cellular Biology.
Dr. Neiditch completed his postdoctoral work at Princeton University in 2007, using X-ray crystallography,
biochemistry, and molecular genetics to study the mechanistic basis of bacterial cell-cell signaling, also
known as quorum sensing. Quorum sensing enables communities of bacteria to coordinate their gene
expression and, in turn, regulate phenotypes such as virulence and antibiotic resistance. Dr. Neiditch???s
studies revealed how secreted quorum-sensing signals and other environmental signals are detected by
receptors at the bacterial surface and transduced across the cell membrane to regulate gene expression.
These studies of receptor molecular recognition, signal transduction, and the regulation of bacterial
pathogenesis were published in Cell, Molecular Cell, and Methods in Enzymology.
Dr. Neiditch joined NJMS as an assistant professor in 2007, was promoted to Associate Professor in 2013,
and Professor in 2021. Dr. Neiditch is a Member of the Center for Immunity and Inflammation and a
Preceptor at the New Jersey Alliance of Clinical and Translational Science Academy of Mentors. He has
been interim chair of the Department of Microbiology, Biochemistry, and Molecular Genetics since 2025.
Education
PHD, 2002, Baylor College of Medicine BS, 1996, Rutgers University
Course List
Structural Biology of Bacteria
Dr. Neiditch's lab at Rutgers NJMS employs a powerful combination of diverse methods, including
biochemical, genetic, computational,
and biophysical techniques (mainly X-ray crystallographic and cryo-EM), to study fundamentally important
and broadly conserved
cellular processes in bacteria. Areas of investigation in his lab include, among others, quorum sensing in
Gram-positive and Gram-
negative bacteria; bacterial phage immunity; mechanisms of horizontal gene transfer, including natural
transformation; and the
development of drugs targeting Mycobacterium tuberculosis, non-tuberculous mycobacteria, and Vibrio
cholerae. He holds patents in
the areas of bacterial anti-infectives and antibiotics.
