Dr. Muriel Lambert received her Ph.D. degree from Northwestern University. Dr. Lambert continued her training as a post-doctoral fellow at Harvard University, followed by a post- doctoral fellowship in the Department of Dermatology at Yale University School of Medicine. Dr. Lambert has been an NIH funded investigator whose research focus has been on the role of DNA repair in genomic stability in genetic diseases defective in DNA repair. She is particularly interested in the underlying mechanism for the hematological disorder, Fanconi anemia (FA), characterized by defective DNA repair, genomic instability and a marked predisposition to develop cancer. Her laboratory has demonstrated that the structural protein, non-erythroid alpha-spectrin (aIISp), is present in cell nuclei where it plays a role in DNA repair, telomere maintenance and chromosomal stability. Her lab has shown that there is a deficiency in aIISp in FA cells due to its decreased stability and this leads to a number of the phenotypic defects observed in these cells. Current
research is focusing on methods to reverse the instability or breakdown of aIISp in FA cells so as to enhance genomic stability and reverse the defects in the cellular phenotype observed. Dr. Lambert is course director of a widely subscribed course, Cellular Pathology, as well as the course, DNA Repair in Health and Disease.
PHD, 1970, Northwestern University
B.A., 1966, Sweet Bliar College, Sweet Briar, VA
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