Overview

Education:
Fordham University, B.S. (Biology)
Columbia University, M. Phil. (Cell Biology), Ph.D. (Cell Biology), M.D.

Professional Experience:
Postdoctoral Fellow, D'Adamio Lab, Albert Einstein College of Medicine
Postdoctoral Fellow, D'Adamio Lab, Rutgers University
Assistant Professor, Rutgers University

Education

MD, 2016, Columbia University, College of Physicians and Surgeons
PHD, 2015, Columbia University, College of Physicians and Surgeons

Relevant Publications

Yesiltepe M*, Yin T*, Tambini MD*, Breuillaud L, Zehntner SP, D'Adamio L. Late-long-term potentiation magnitude, but not A?? levels and amyloid pathology, is associated with behavioral performance in a rat knock-in model of Alzheimer disease. Front Aging Neurosci. 2022 Nov 11;14:1040576.

Ran S*, Yao W*, Tambini MD, Yin T, Norris KA, and D'Adamio L. Microglia TREM2R47H Alzheimerlinked variant enhances excitatory transmission and reduces LTP via increased TNF-?? levels. eLife. 2020 Jun 24;9:e57513

Tambini MD and D'Adamio L. Rat knock-in model of the Presenilin-1 L435F Alzheimer's mutation shows survival in homozygosity and selective loss of ??-secretase activity. Journal of Biological Chemistry. 2020 Apr 7. pii: jbc.RA120.012542

Tambini MD and D'Adamio L. Trem2 Splicing and Expression are Preserved in a Human A??producing, Rat Knock-in Model of Trem2-R47H Alzheimer's Risk Variant. Scientific Reports. 2020 10, 4122

Tambini MD, Norris KA, and D'Adamio L. Opposite Changes in APP Processing and Human A?? Levels in Rats Carrying Either a Protective or a Pathogenic APP Mutation. eLife. 2020;9:e52612

Tambini MD*, Yao W*, and D'Adamio L. Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock-in rats with increased ??-cleavage of APP. Aging Cell. 2019 Sep 9:e13033

Yao W*, Tambini MD*, Liu X, and D'Adamio L. Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by ?? or ??-secretase cleavage. Journal of Neuroscience. 2019 Jun 24. pii: 0207-19

Yao W*, Yin T*, Tambini MD*, and D'Adamio L. The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms. Scientific Reports. 2019 Mar 19;9(1):4862

Biundo F, d'Abramo C, Tambini MD, Zhang H, Del Prete D, Vitale F, Giliberto L, Arancio O, and D'Adamio L. Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations. Translational Psychiatry. 2017 Aug 8;7(8):e1198

Tambini MD, Pera M, Kanter E, Yang H, Guardia-Laguarta C, Holtzman D, Sulzer D, Area-Gomez E, and Schon E. ApoE4 upregulates the activity of mitochondriaassociated ER membranes. EMBO Reports. 2016 Jan;17(1):27-36

Areas Of Interest

Alzheimer's disease

amyloid precursor protein

animal models of neurodegeneration

extracellular vesicles

neurodegeneration