Joseph J McArdle joined the NJMS in 1972 after completing PhD and postdoctoral studies in Cellular Neuropharmacology at the State University of New York at Buffalo. His work in synapse development, pathophysiology, and pharmacology has grown as a result of sabbatical leaves with Alberto Mallart (CNRS), Peter W Gage (Australian National University), Phillip Nelson (NIH), and Veit Witzemann (Max-Planck Institute for Medical Research). This work utilizes target-selective neurotoxins as well as transgenic mice to discover the function(s) of proteins that are essential to synapse development and health. The work focuses on the neuromuscular junction because of the rich knowledge of the molecular basis of normal transmission across this model synapse. Dr. McArdle's work extends this knowledge to mouse models of diseases that target molecules critical to synaptic transmission; e.g., diabetic neuropathy, ALS, botulism, myasthenia gravis. McArdle has extended the techniques and concepts related to neuromuscular junction research to studies of cardiac arrhythmias as well as the molecular action of addictive drugs. Numerous scholars have studied in McArdle's laboratory including postdoctoral fellows (approximately 11), as well as PhD (12) and Masters (6) students. The work from McArdle's lab is presented in more than 100 peer reviewed articles. McArdle served on review panels of the NSF and NIH and continues to review grants applications as well as scientific manuscripts.
Ph.D., 1971, State University of New York at Buffalo
B.A., 1967, University of Delaware
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