Department of Pharmacology, Physiology & Neuroscience

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   Joseph J. Mc Ardle, PHD


Department of Pharmacology, Physiology & Neuroscience
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Joseph J McArdle joined the NJMS in 1972 after completing PhD and postdoctoral studies in Cellular Neuropharmacology in the
laboratory of Edson X Albuquerque at the State University of New York at Buffalo. His study of synapse development,
pathophysiology, and pharmacology has grown as a result of sabbatical leaves with Alberto Mallart (CNRS), Peter W Gage
(Australian National University), Phillip Nelson (NIH), and Veit Witzemann (Max-Planck Institute for Medical Research). This
work utilizes target-selective neurotoxins as well as transgenic mice to discover the function(s) of proteins that are essential to
synapse development and health. The work focuses on the neuromuscular junction because of the rich knowledge of the
molecular basis of normal transmission across this model synapse. McArdle's work extends this knowledge to mouse models of
diseases that target molecules critical to synaptic transmission, e.g., diabetic neuropathy, ALS, botulism, myasthenia gravis.
McArdle has extended the techniques and concepts related to neuromuscular junction research to studies of cardiac
arrhythmias as well as the molecular action of addictive drugs. Numerous scholars have studied in McArdle's laboratory
including postdoctoral fellows (approximately 11), as well as PhD (12) and Masters (6) students. The work from McArdle's lab is
presented in more than 100 peer reviewed articles. McArdle served on review panels of the NSF and NIH and, as Emeritus
Professor continues to review grants applications as well as scientific manuscripts.


PHD, 1971, State University of New York at Buffalo
B.A., 1967, University of Delaware

Curriculum Vitae

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