Department of Pharmacology, Physiology & Neuroscience

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   Joseph J. Mc Ardle, Ph.D.


Department of Pharmacology, Physiology & Neuroscience



Joseph J McArdle joined the NJMS in 1972 after completing PhD and postdoctoral
studies in Cellular Neuropharmacology at the State University of New York at Buffalo.
His work in synapse development, pathophysiology, and pharmacology has grown as a
result of sabbatical leaves with Alberto Mallart (CNRS), Peter W Gage (Australian
National University), Phillip Nelson (NIH), and Veit Witzemann (Max-Planck Institute
for Medical Research). This work utilizes target-selective neurotoxins as well as
transgenic mice to discover the function(s) of proteins that are essential to synapse
development and health. The work focuses on the neuromuscular junction because of the
rich knowledge of the molecular basis of normal transmission across this model
synapse. Dr. McArdle's work extends this knowledge to mouse models of diseases that
target molecules critical to synaptic transmission; e.g., diabetic neuropathy, ALS,
botulism, myasthenia gravis. McArdle has extended the techniques and concepts related
to neuromuscular junction research to studies of cardiac arrhythmias as well as the
molecular action of addictive drugs. Numerous scholars have studied in McArdle's
laboratory including postdoctoral fellows (approximately 11), as well as PhD (12) and
Masters (6) students. The work from McArdle's lab is presented in more than 100 peer
reviewed articles. McArdle served on review panels of the NSF and NIH and continues
to review grants applications as well as scie


Ph.D., 1971, State University of New York at Buffalo
B.A., 1967, University of Delaware

Curriculum Vitae

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