Overview

EDUCATION:
A. Undergraduate
University of North Carolina
Chapel Hill, NC
B.S. Biology with Highest Honors 1984
B. Graduate
Duke University
Durham, NC
Ph.D. Microbiology and Genetics 1990

POST GRADUATE TRAINING:
A. Internships and Residencies: N/A

B. Research Fellowships

C. Postdoctoral Appointments
Phillips-Universtat Marburg, Germany (Dr. Reinhard Luhrmann),
Discipline Molecular Biology
Winter 1990-1991

Children?s Hospital of Philadelphia (Dr. Michael Zasloff)
Discipline Genetics and Molecular Biology
July 1991-June 1992

University of Pennsylvania (Dr. James Alwine)
Discipline Molecular Biology
July 1992-December 1997

Education

PHD, 1990, Duke University, Microbiology and Genetics
B.S., 1984, University of North Carolina-Chapel Hill

Relevant Publications

Newnham CM, Hall-Pogar T, Liang S, Wang J, Tian B, Hu J, Lutz CS. (2010) Alternative polyadenylation of MeCP2: influence of cis-acting elements and trans-acting factors. RNA Biology 7: 364-375.

Lutz CS, Moreira AM. (2011). Alternative polyadenylation of eukaryotic mRNAs: an effective regulator of gene expression. WIREs RNA 2: 22-31

Bronzoni RVM, Madrid MCFS, Duarte DVB, Pellegrini VOA, Pacca, CC, Carmo ACV, Zanelli CF, Valentini SR, Santacruz-Perez C, Barbosa JARG, Lutz CS, Rahal P, Nogueira ML. (2011) The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus and other flaviviruses. Archives of Virology, 156: 931-938.

Lutz CS. (2008). Alternative polyadenylation: a twist on 3? end formation. Invited review article, ACS Chemical Biology, 3: 609-617.

Darmon SK, and Lutz CS. (2012) mRNA 3? end processing factors: a phylogenetic comparison. Comparative and Functional Genomics, 876893. Epub 2012 Feb 6.

Kasar S, Underbayev C, Hassan M, Tata D, Ilev I, Degheidy H, Marti G, Lutz CS, Raveche E, Batish M. Alterations in the mir-15a/16-1 Loci Impairs its Processing and Augments B-1 Expansion in De Novo Mouse Model of Chronic Lymphocytic Leukemia (CLL). PLoS One. 2016 Mar 9;11(3):e0149331. doi: 10.1371/journal.pone.0149331. eCollection (2016).

Monteleone NJ, Lutz CS. MiR-708-5p: A MicroRNA with Emerging Roles in Cancer. Oncotarget. (2017) Aug 1;8(41):71292-71316. doi: 10.18632/oncotarget.19772. eCollection 2017 Sep 19.

Iacona JR, Monteleone NJ, Lutz CS. miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells (2018). Oncotarget 9:26751-26769. https://doi.org/10.18632/oncotarget.25482

Shukla S, Elson G, Blackshear P, Lutz CS and Leibovich SJ. 3?UTR AU-rich elements (AREs) and the RNA-Binding Protein Tristetraprolin (TTP) are not required for the LPS-mediated destabilization of phospholipase-C?-2 mRNA in murine macrophages. Inflammation. 2017 Jan 25. doi: 10.1007/s10753-017-0511-y. [Epub ahead of print]

Shukla S, Levine C, Sripathi RP, Elson G, Lutz CS, Leibovich SJ. The Kat in the HAT: the histone acetyl transferase Kat6B (MYST4) is downregulated in murine macrophages in response to LPS. (2018) Mediators of Inflammation, 2018 Jun 6;2018:7852742. doi: 10.1155/2018/7852742. eCollection 2018

Areas Of Interest

3' end formation

RNA processing

arachidonic acid metabolic pathway

cancer

inflammation

miRNA

regulation of gene expression