Overview

Hong Li, Ph.D. is the Director of the Center for Advanced Metabolomics & Proteomics
Research at Rutgers New Jersey Medical School and a faculty member in the
Department of Microbiology, Biochemistry, and Molecular Genetics. He leads strategic
development and application of advanced metabolomics, proteomics, and spatial
molecular technologies, supporting interdisciplinary research and translational
discovery across the biomedical sciences.

Grants and Publications: https://orcid.org/0000-0001-5731-5335?lang=en
Research Impact: https://www.researchwithrutgers.com/en/persons/hong-li/

Education

PHD, 1997, University of Nevada
BS, 1992, University of Nevada

Curriculum Vitae

View CV

Languages

Chinese

Relevant Publications

Han X, Shen J, Yan J, Tacke R, Dai W, Mao Q, Queen Daguplo H, Liu S, Islam A, Liu T, Koch MC, Lin RZ, Li H, Anthony T, Xie P, Zhang L, Gao S, Simon MC, Chen X, Yang J, Su X, Zong WX. Impaired nitrogenous waste clearance promotes hepatocellular carcinoma. Sci Adv. 2026 Jan 9;12(2):eaec0766. doi: 10.1126/sciadv.aec0766. Epub 2026 Jan 9. PMID: 41512056; PMCID: PMC12787525.

Nakada Y, Titus AS, Mizushima W, Yang Y, Zhai P, Tian Y, Oka S, Kashihara T, Fefelova N, Pamarthi SH, Liu T, Li H, Xie LH, Takayama K, Ikeda S, Matsushita M, Huang CY, Hsu CP, Onoue K, Saito Y, Sadoshima J. p22phox prevents the oxidation of SERCA2a and stabilizes it in the heart. Nat Cardiovasc Res. 2025 Sep;4(9):1187-1205. doi: 10.1038/s44161-025-00699-x. Epub 2025 Sep 3. PMID: 40903547; PMCID: PMC12436179.

Keller MA, Ivessa A, Liu T, Li H, Romanienko PJ, Nakamura M. KAT6A acetylation regulates AMPK function and hypertrophic remodeling in the heart. Mol Metab. 2025 Aug 25;101:102239. doi: 10.1016/j.molmet.2025.102239. Epub ahead of print. PMID: 40865637.

Nanditha Anandakrishnan, Zhengzi Yi, Zeguo Sun, Tong Liu, Jonathan Haydak, Sean Eddy, Pushkala Jayaraman, Stefanie DeFronzo, Aparna Saha, Qian Sun, Dai Yang, Anthony Mendoza, Gohar Mosoyan, Huei Hsun Wen, Jia Fu, Thomas Kehrer, Rajasree Menon, Edgar A. Otto, Bradley Godfrey, Joanna Yang, Mayte Suarez-Farinas, Sean Leffters, Akosua Twumasi, Kristin Meliambro, Alexander W. Charney, Adolfo Garc??a- Sastre, Kirk N. Campbell, G. Luca Gusella, John Cijiang He, Lisa Miorin, Girish N. Nadkarni, Juan Wisnivesky, Hong Li, Matthias Kretzler, Steve G. Coca, Lili Chan, Weijia Zhang, Evren U. Azeloglu, Liquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity, Kidney International Reports, 2025. https://doi.org/10.1016/j.ekir.2025.07.021.

Sun Z, Yi Z, Wei C, Wang W, Ren T, Cravedi P, Tedla F, Ward SC, Azeloglu E, Schrider DR, Li Y, Khan A, Zanoni F, Fu J, Ali S, Liu S, Liang D, Liu T, Li H, Xi C, Vy TH, Mosoyan G, Sun Q, Kumar A, Zhang Z, Farouk S, Campell K, Ochando J, Lee K, Coca S, Xiang J, Connolly P, Gallon L, O'Connell PJ, Colvin R, Menon MC, Nadkarni G, He JC, Kraft M, Jiang X, Zhang X, Kiryluk K, Cherukuri A, Lakkis FG, Zhang W, Chen SH, Heeger PS, Zhang W. LILRB3 genetic variation is associated with kidney transplant failure in African American recipients. Nat Med. 2025 Mar 10. doi: 10.1038/s41591- 025-03568-z. Epub ahead of print. Erratum in: Nat Med. 2025 Apr 15. doi: 10.1038/s41591-025-03706-7. PMID: 40065170.

Vidovi?? D, Shamsaei B, Sch??rer SC, Kogan P, Chojnacki S, Kouril M, Medvedovic M, Niu W, Azeloglu EU, Birtwistle MR, Chen Y, Chen T, Hansen J, Hu B, Iyengar R, Jayaraman G, Li H, Liu T, Sobie EA, Xiong Y, Berberich MJ, Bradshaw G, Chung M, Everley RA, Gaudio B, Hafner M, Kalocsay M, Mills CE, Nariya MK, Sorger PK, Subramanian K, Victor C, Banuelos M, Dardov V, Holewinski R, Manalo DM, Mandefro B, Matlock AD, Ornelas L, Sareen D, Svendsen CN, Vaibhav V, Van Eyk JE, Venkatraman V, Finkbiener S, Fraenkel E, Rothstein J, Thompson L, Asiedu J, Carr SA, Christianson KE, Davison D, Dele-Oni DO, DeRuff KC, Egri SB, Jacome ASV, Jaffe JD, Lam D, Litichevskiy L, Lu X, Mullahoo J, Officer A, Papanastasiou M, Peckner R, Toder C, Blanchard J, Bula M, Ko T, Tsai LH, Young JZ, Sharma V, Pillai A, Meller J, MacCoss MJ. Comprehensive proteomics metadata and integrative web portals facilitate the sharing and integration of LINCS multiomics data. Mol Cell Proteomics. 2025 Mar 13:100947. doi: 10.1016/j.mcpro.2025.100947. Epub ahead of print. PMID: 40089066.

Yang P, Gao S, Shen J, Liu T, Lu K, Han X, Wang J, Ni HM, Ding WX, Li H, Pan JA, Peng K, Zong WX. TRIM21-mediated ubiquitination of SQSTM1/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity. Autophagy. 2025 Jan;21(1):178- 190. doi: 10.1080/15548627.2024.2394308. Epub 2024 Sep 10. PMID: 39172027; PMCID: PMC11702951.

Dasgupta S, Pandya MA, Zanin JP, Liu T, Sun Q, Li H, Friedman WJ. ProNGF elicits retrograde axonal degeneration of basal forebrain neurons through p75NTR and induction of amyloid precursor protein. Sci Signal. 2024 Sep 24;17(855):eadn2616. doi: 10.1126/scisignal.adn2616. Epub 2024 Sep 24. PMID: 39316663; PMCID: PMC11487763.

Maejima Y, Nah J, Aryan Z, Zhai P, Sung EA, Liu T, Takayama K, Moghadami S, Sasano T, Li H, Sadoshima J. Mst1-mediated phosphorylation of FoxO1 and C/EBP-?? stimulates cell-protective mechanisms in cardiomyocytes. Nat Commun. 2024 Jul 25;15(1):6279. doi: 10.1038/s41467-024-50393-y. PMID: 39060225; PMCID: PMC11282193.

Zhou D, Nouet J, Mesa E, Yegneshwaran V, Geukgeuzian G, Adibemma ID, Ramirez E, Ali NK, Hilfiker S, Li H, Liu T, Yehia G, Romanienko PJ, Rodney GG, Wehrens XHT, Lampe PD, Gourdie RG, Xie LH, Fraidenraich D. Phospho-mimic ??III-tubulin rescues microtubule and cardiac defects in Duchenne muscular dystrophy mice. J Mol Cell Cardiol. 2026 Apr 17:S0022-2828(26)00055-6. doi: 10.1016/j.yjmcc.2026.04.004. Epub ahead of print. PMID: 42001993.

Areas Of Interest

Bioinformatics

Methylation

Nitrosylation

Phosphoproteomics

Phosphorylation

Proteomics

SILAC

Spatial Metabolomics

TMT

Technology Solutions

iTRAQ

Course List

GSND5200Q		Intro to Biomedical Sciences
GSND5205Q		Genes & Molecules in Medicine

An Orbitrap Astral Mass Spectrometer for Elevating Proteomics Sensitivity at Rutgers Biomedical and

Project Summary/Abstract The Rutgers Biomedical and Health Sciences
(RBHS) seeks NIH support to acquire a Thermo Orbitrap Astral mass spectrometer
(Astral MS) for the Center for Advanced Proteomics Research (CAPR) on its Newark
campus. CAPR supports over 150 NIH-sponsored projects. The influx of research
grants at Rutgers, growing from $644 million to $929 million from FY14 to FY24, has
increased demand for mass spectrometry services at CAPR. While once cutting-edge,
the existing Thermo Lumos Tribrid MS is now inadequate for many sensitivity-
demanding projects due to its limited sensitivity and impending obsolescence. The
Astral MS, with its enhanced data-independent acquisition (DIA) sensitivity, can detect
over 10,000 human proteins, a crucial capability for integrating proteomic data with
RNA-seq and discovering changes in protein expression and post-translational
modifications. It also significantly improves data-dependent analysis of
immunopeptidomes, a vital aspect of cancer immunotherapy and vaccine
development, by detecting low- abundance peptides more effectively. Comparative
evaluations revealed the superiority of the Astral MS in identifying low-abundance
proteins and peptides compared to the Lumos and new Bruker timsTOF Ultra MS. The
Astral MS detected over 60% more phosphopeptides and 100% more proteins than
the Lumos MS and significantly more immunopeptides, highlighting its potential to
revolutionize CAPR proteomic research support capabilities. Operational practicalities
have been thoroughly considered, with a smooth integration of the Astral MS
anticipated, given CAPR's familiarity with Thermo instruments and software. CAPR is
confident in the substantial benefits that this instrument's exceptional sensitivity and
speed enhancements will bring, bolstering sensitivity and service capacity for the
users. Incorporating an Astral MS will effectively address sensitivity requirements
among our 16 major users and 10 minor users, who have substantiated their needs for
this new instrument based on the scientific aims of their NIH-funded research
projects. Acquiring a Thermo Orbitrap Astral mass spectrometer is critical for CAPR to
continue supporting NIH-funded investigations, enhance their DIA quantification
sensitivity and DDA immunopeptidome sensitivity, and stay at the forefront of the
rapidly evolving proteomics field.