Medical Science Building (MSB) 185 South Orange Avenue Room E649 Newark, NJ 07101 Phone: (973) 972-5345 Fax: (973) 972-5594
Ph.D., 1964, University of Birmingham, England, Not Available B.S., 1961, University of Birmingham, England, Biochemistry Ph.D., 1964, University of Birmingham, Biochemistry
M.A. Lea, A. Shareef, M. Sura and C.desBordes. Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules. Cancer Chemother. Pharmacol., 54, 57-63, 2004.
M.A. Lea, C. Ibeh, N. Shah and M.P. Moyer. Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase. Anticancer Res., 27, 741-748, 2007.
M.A.Lea, C. Ibeh, C. desBordes, M. Vizzotto, L. Cisneros-Zevallos, D.H. Byrne, W.R. Okie and M.P. Moyer. Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds. Anticancer Res., 28, 2067-2076, 2008.
M.A. Lea, C. Ibeh, L.Han and C. desBordes. Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells. Anticancer Res., 30, 311-318, 2010.
M.A. Lea. Recent and potential targets for treating colon cancer. Future Oncol., 6, 993-1002, 2010.
M.A. Lea, C. Ibeh, J.K. Deutsch, I. Hamid and C. desBordes. Inhibition of growth and induction of alkaline phosphatase in colon cancer cells by flavonols and flavonol glycosides. Anticancer Res., 30: 3629-3636, 2010.
M.A. Lea, J. Chacko, S. Bolikal, J.Y. Hong, R. Chung, A. Ortega and C. desBordes. Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin, Anticancer Res., 31: 421-426, 2011.
M.A.Lea. Fruit phenolics in colon cancer prevention and treatment. In: Bioactive Foods and Extracts: Cancer Treatment and Prevention. R.R. Watson and V.R. Preedy (eds.) Boca Raton, FL, CRC Press, p. 415-426 (2011).
B. Dayal, V.R. Yannamreddy, A.P. Singh, M. Lea and N.H. Ertel. Bioactive compounds from okra seeds: potential inhibitors of advanced glycation end products. In: Emerging Trends in Dietary Components for Preventing and Combating Disease. ACS Symposium Series Vol. 1093, Chapter 16, pp. 287-302, 2012.
M.A, Lea. Compounds in vegetables including okra and fenugreek of potential value in the treatment of diabetes. In: Bioactive Food as Dietary Interventions for Diabetes, R.R. Watson and V.R. Preedy (eds.) San Diego: Academic Press, pp. 291-306 (2013).
Regulation of growth and differentiation in cancer
My research has been directed to an understanding of cancer growth and differentiation and has focused particularly on cancer of the liver and colon. In recent years I have investigated actions of dietary derived natural products on cancer cell proliferation and differentiation. The compounds that were studied included short-chain fatty acids, isothiocyanates, allyl sulfur compounds and polyphenolic molecules. These compounds can act through a variety of mechanisms including modification of histone side-chains, inhibition of protein kinases and anti-oxidant effects. These effects can be exerted by a number of molecules derived from fruits and vegetables.