Overview

Ioana grew up in Romania, where she studied general medicine. She moved to the US for her doctoral studies on developmental mechanisms of neural circuit assembly, working with Deanna Benson at Mount Sinai School of Medicine. She then worked with Robert Froemke at NYU School of Medicine, on neuromodulatory mechanisms for auditory perception, attention and social (maternal) behavior.

Education

PHD, 2010, Mount Sinai School of Medicine
MD, 2003, University of Medicine and Pharmacy 'Gr. T. Popa', Iasi, IS

Curriculum Vitae

View CV

Relevant Publications

Oxytocin transforms firing mode of CA2 hippocmpal neurons, Tirko NT, Eyring KW, Carcea I, Mitre M, Chao MV, Froemke RC, Tsien RW (Neuron 2018)

Locus coeruleus activation accelerates perceptual learning, Glennon E, Carcea I, Martins ARO, Multani J, Shehu I, Svirsky MA, Froemke RC (Brain Res. 2018)

Dynamics of auditory cortical activity during behavioural engagement and auditory perception. Carcea I, Insanally MN, Froemke RC (Nat Commun. 2017)

Maturation of cortical circuits requires Semaphorin 7A. Carcea I, Patil SB, Robison AJ, Mesias R, Huntsman MM, Froemke RC, Buxbaum JD, Huntley GW, Benson DL.(PNAS 2014)

Cortical plasticity, excitatory-inhibitory balance, and sensory perception. Carcea I, Froemke RC (Prog Brain Res. 2013)

Long-term modification of cortical synapses improves sensory perception. Froemke RC, Carcea I, Barker AJ, Yuan K, Seybold BA, Martins AR, Zaika N, Bernstein H, Wachs M, Levis PA, Polley DB, Merzenich MM, Schreiner CE. (Nat. Neurosci. 2013)

L1 cell adhesion molecule promotes resistance to alcohol-induced silencing of growth cone responses to guidance cues. Sepulveda B, Carcea I, Zhao B, Salton SR, Benson DL. (Neuroscience. 2011)

Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A. Carcea I, Ma?ayan A, Mesias R, Sepulveda B, Salton SR, Benson DL.(J Neurosci. 2010)

ERM proteins regulate growth cone responses to Sema3A. Mintz CD, Carcea I, McNickle DG, Dickson TC, Ge Y, Salton SR, Benson DL. (J Comp Neurol. 2008)

Areas Of Interest

neural plasticity

neuromodulation

oxytocin

social behavior

Neuromodulation and social behavior

The quality and quantity of social interactions are some of the best predictors for mental health and for longevity in humans. However, the biological mechanisms by which these interactions can have such profound effects on our brain and behavior remain largely a mystery. In our lab, we use animal models to investigate these mechanisms at the behavioral, electrophysiological and neurochemical levels. One of the circuits we probe in this context is the oxytocinergic system in mice. We approach this from three different angles.

1. Maternal behavior
The first and arguably the most impactful social interaction experienced in life is the interaction with parents. In mammals, the quality of parental care is key to the survival of offsprings. But what is the neural substrate for good parental behavior?
We investigate neural substrates for some key maternal behaviors. In particular, we are interested in understanding how maternal mice recruit the help of other adult mice in order to provide optimal care for offsprings. In this context, we investigate sensory processing of pup-related cues, and how it might result in activating the oxytocinergic system.


2. Social buffering
Certain social contexts, like the presence of familiar conspecifics, can alleviate the stress induced by dangerous environments, a phenomenon called social buffering. Other social situations can have the opposite effect, aggravating the stress response. For example, one can respond to a scream either by running away (fight-or-flight) or by offering comfort (tend-and-befriend), depending on social, circumstances.
Our research will investigate the neural circuits by which social contexts modulate auditory processing and behavior. We will use electrophysiological, functional imaging, optogenetic and pharmacogenetic techniques in mice to study the role of cortical and subcortical circuits in social modulation of auditory representations.


3. Social Learning and Memory
Animals can capitalizes on the presence and experience of another to change their own behavior. This form of learning is an efficient strategy for adapting to changes in environmental conditions, but little is known about the underlying neural mechanisms. A good candidate is the oxytocinergic neuromodulatory system, which has been previously implicated in social learning.
We investigate whether oxytocin can modulate neuronal activity in major brain structures important for memory formation (frontal cortex, hippocampus, amygdala, etc). To address the potential beneficial role of social learning in dementia, we will investigate oxytocin activity in aged and Alzheimer?s Disease rodent models.