Overview

Disease rescue by pluripotent stem cells.
nNOS and connexin-43 roles in Duchenne Muscular Dystrophy-cardiomyopathy
Epimorphic effects of pluripotent stem cells

Education

MSC, 1990, School of Sciences, Univerity of Buenos Aires
PHD, 1994, INGEBI, University of Buenos Aires

Curriculum Vitae

View CV

Languages

Spanish

Relevant Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=fraidenraich+d

Areas Of Interest

IGF1

IGFBP3

Id

Mst1

WNT

cardiomyopathy

cardiovascular biology

chimeras

congenital heart disease

embryonic stem cells

induced pluripotent stem cells

mdx

mesenchymal stem cells

mouse models

muscular dystrophy

sarcoglycan delta

utrophin

Course List

CBMM5020Q		Devel Biology & Stem Cells
CBNP5068Q		Mechanisms of Disease
CBNP5037Q		Regenerative Medicine
GSND5200Q		Intro to Biomedical Sciences
GSNDN500B		Fundamentals B: Cell Biology

Stem cell disease correction in mice

One main focus of my lab is to design paradigms for embryonic stem (ES) and induced pluripotent stem (iPS) cell based repair of
cardiac and skeletal muscle defects using mouse models of human disease (thin myocardial syndrome, cardiomyopathy, muscular
dystrophy). Another focus is to study paracrine non-myocardial factors in Id KO embryos/mice, a model of congenital heart disease
and adult fibrotic cardiomyopathy. The ultimate goal is to identify cardiotrophic and myotrophic factors with rescue potential.
We also produce human iPS cell - derived cardiomyocytes and other cell types, to model disease in the dish.

for additional information please visit:

http://njms.umdnj.edu/departments/cell_biology_and_molecular_medicine/labs/fraidenraich/aboutourlab.cfm
http://njms.rutgers.edu/departments/cell_biology_and_molecular_medicine/hicc_intro.cfm