Dr Ferraris received his undergraduate and graduate degrees in Biology (Xavier
University, Philippines) and Zoology (University of Hawaii) then worked briefly for
international development agencies serving Southeast Asia. Political upheaval in his
native Philippines forced an early career shift, and he was fortunate to receive a
postdoctoral fellowship at UCLA in Professor Jared Diamond?s laboratory to
study the intestinal epithelium and identify the cell types able to perceive luminal
signals that ultimately determine site density of sugar transporters. This sparked
his lifelong interest in studying integrative regulatory processes involving nutrient
transport and metabolism. He is currently using intestinal organoids to determine
whether pure cultures of intestinal stem and of terminally differentiated absorptive
cells can perceive and respond to luminal signals
Ph.D., 1982, University of Hawaii M.S., 1977, University of Hawaii B.S., 1974, Xavier University, Philippines
1. Yu S, Tong K, Zhao Y, Balasubramanian I, Yap G.S., Ferraris R.P., Bonder E.M.,
Verzi M.P., Gao N. Paneth cell multi-potency induced by Notch activation following
injury. Cell Stem Cell. 2018, 23(1): 46-59 PMID: 29887318
2. Ferraris R.P., Choe J.Y., Patel C.R. Intestinal absorption of fructose. Annu Rev
Nutr. 2018, 38:41-67. PMID: 2975173 (review)
3. Pearce SC, Al-Jawadi A, Kishida K, Yu S, Hu M, Fritzky LF, Edelblum KL, Gao N,
Ferraris RP. Marked differences in tight junction composition and macromolecular
permeability among different intestinal cell types. BMC Biol. 2018, 16(1):19.
doi:10.1186/s12915-018-0481-z. PMID: 29391007
4. Kishida K, Pearce SC, Yu S, Gao N, Ferraris RP. Nutrient sensing by absorptive
and secretory progenies of small intestinal stem cells. Am J Physiol GI & Liver. 2017,
312(6):G592-605. PMID: 28336548
5. Kemp FW, Portugal F, Akudugu JM, Neti PV, Ferraris RP, Howell RW. Vitamins A, C,
and E May Reduce Intestinal 210Po Levels after Ingestion. Health Phys. 2016, 111(1):52-7.
6. Roche M, Neti PV, Kemp FW, Azzam EI, Ferraris RP, Howell RW. High Levels of
Dietary Supplement Vitamins A, C and E are Absorbed in the Small Intestine and Protect
Nutrient Transport Against Chronic Gamma Irradiation. Radiat Res. 2015, 184(5):470-81.
7. Patel CR, Sugimoto, K, Douard V, Shah A, Inui H, Yamanouchi T, and Ferraris RP.
Effect of dietary fructose on portal and systemic serum fructose levels in rats and in
KHK-/- and GLUT5-/- mice. Am J Physiology, GI & Liver Physiol. 2015, 309(9):G779-90.
8. Patel CR, Douard V, Yu S, Tharabenjasin P, Gao N, Ferraris RP. Fructose-induced
increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by
GLUT5 and KHK. Am J Physiol Regul Integr Comp Physiol. 2015, 309(5):R499-509. PMID:
9. Patel C, Douard V, Yu S, Gao N, Ferraris RP. Transport, metabolism, and endosomal
trafficking-dependent regulation of intestinal fructose absorption. FASEB J. 2015,
29(9):4046-58. PMID: 26071406
10. Sakamori R, Das S, Yu S, Feng S, Stypulkowski E, Guan Y, Douard V, Tang W,
Ferraris RP, Harada A, Brakebusch C, Guo W, Gao N. Cdc42 and Rab8a are critical for
intestinal stem cell division, survival, and differentiation in mice. J Clin Invest.
2012, 122(3):1052-65. PMID: 22354172
Areas Of Interest
Role of differentiation in modulating plasticity of epithelial cells; fructose metabolism & obesity
Endocrine regulation of signaling mechanisms and nuclear receptors modulating
transcription of nutrient transporters; enteric and hepatic oxidative stress arising
from sugar metabolism and radiation damage; cell differentiation and nutrient signaling
in intestinal epithelia; probiotics and gut microbiome in neonatal intestine