Department of Pharmacology, Physiology & Neuroscience


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   Paula J. Bartlett, PhD, Bsc

Assistant Professor-Research
Assistant Professor

Department of Pharmacology, Physiology & Neuroscience
bartlepj@njms.rutgers.edu

 


Overview

My research focus is to understand the mechanisms which elicit and maintain hormone-induced Ca2+ oscillations in the liver. Hepatocytes display stimulus-strength regulated Ca2+ oscillations and waves when challenged with hormones, such as vasopressin and glucagon, which couple to PLC-linked GPCRs. My research utilizes single cell imaging techniques and photorelease of caged IP3 to dissect the mechanisms regulating oscillations. I have demonstrated multiple proteins involved in the Ca2+ signalling pathway are regulated by PKC which provides both positive and negative feedback mechanisms to shape Ca2+ responses.

More recently my research has focused on Ca2+ dysfunction and the role this plays in the pathogenesis of disease states such as alcoholic and non-alcoholic fatty liver disease. Many primary functions of the liver are regulated by signaling mechanisms that manifest as cytosolic Ca2+ ([Ca2+]c) oscillations, including glucose metabolism, mitochondrial physiology and gene expression. I have shown, chronic alcohol consumption sensitizes hepatocytes to PLC-linked hormones, potentiating Ca2+ signals and increasing cellular oxidative stress. My current research aims to delineate the effects of high fat diet on hormone-dependent calcium signaling in hepatocytes, in particular how these contribute to the dysregulation glucose homeostasis and the role this plays in the development of hepatic insulin resistance and diabetes.



Education

PhD, 2007, University of Leicester
Bsc, 2000, University of West England