Discovering the function and regulation of chemical modifications to ribosomal RNA in the cell
Ribosomal RNAs (rRNAs) are among the most abundant RNAs in the cell and unlike mRNAs,
are extensively chemically modified. This is true from bacteria to humans. However, we really do not
know what these modifications do, in part due to the difficulty in studying rRNA genes which are
repeated dozens to hundreds of times in the cell. The Olarerin lab is devising new strategies using
biochemistry, molecular biology and computational biology to discover what these modifications do
and how aberrant modifications can result in disease.