Generally, we are interested in the molecular mechanisms that underlie cardiac hypertrophy and failure. One of the major mechanisms involved in the development of heart disease is dysregulation of gene expression at the transcriptional, posttranscriptional, or translational level, which is the focus of our research. Specifically, our interest is in deciphering the histone code that regulates transcriptional activity and its modulation by the type of diet during cardiac hypertrophy and failure.
Education
MD, 1983, University of Alexandria PHD, 1992, University of Maryland PHD, 1992, University of Maryland
Languages
Arabic
Relevant Publications
Public URL to our publications
https://www.ncbi.nlm.nih.gov/myncbi/maha.abdellatif.1/bibliography/public/
National Institute of Health funded research
1. We have recently discovered that metabolic tricarboxylic acid and fatty acid beta-oxidation enzymes reside in the nucleus, as well as, the mitochondria, for which we are investigating their roles in histone modifications.
2. We are also investigating the differential roles of glucose, fatty acids, and amino acids metabolism in histone posttranslational modifications and transcriptional regulation during cardiac hypertrophy and failure.
