Overview

Dr. Edelblum began her training in the Department of Cell & Developmental Biology at Vanderbilt University.
During her graduate training, Dr. Edelblum focused on the role of Raf-1 kinase in intestinal epithelial cell survival
downstream of pro-inflammatory cytokine signaling and in response to acute colitis. Fascinated by the synergy
between immunological, epithelial and microbial factors during the pathogenesis of colitis, she continued her
training at The University of Chicago where she developed novel advanced live imaging approaches to visualize
immune/epithelial interactions in the intestinal mucosa during exposure to enteric pathogens. Combining
traditional cell biology and mucosal immunology techniques has allowed Dr. Edelblum to investigate gamma delta
T cell migration and how direct contact between gamma delta T cells and enterocytes confer protection against
enteric pathogen invasion. Dr. Edelblum?s long-term research interests are to identify how gamma delta T
cell/epithelial interactions shape innate immune responses to pathogenic and commensal bacteria as a means to
treat inflammatory bowel disease.

Education

Ph.D., 2008, Vanderbilt University
B.S., 2002, Emory University

Curriculum Vitae

View CV

Relevant Publications

Edelblum KL, Turner JR. ?The tight junction in inflammatory disease: communication breakdown.? Curr Opin Pharmacol. 2009 Dec;9(6):715-20. PMID: 19632896

Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth C, Guan Y, Montrose MH, Turner JR, Watson AJ. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology. 2011 Apr;140(4):1208-1218.

Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of gamma delta intraepithelial lymphocytes requires occludin. PNAS. 2012 May 1;109(18):7097-102. PMID: 22511722

Nalle SC, Kwak HA, Edelblum KL, Joseph NE, Singh G, Khramtsova GF, Mortenson ED, Savage PA, and Turner JR. Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. Sci Transl Med. 2014 Jul 2;6(243):243ra87. PMID: 24990882

Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI and Turner JR. Gamma delta intraepithelial lymphocyte migration limits transepithelial pathogen invasion and systemic disease in mice. Gastroenterology. 2015 Jun;148(7):1417-26. PMID: 25747597

Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR*. The microbiome activates CD4 T-cell-mediated immunity to compensate for increased intestinal permeability, Cell Mol Gastroenterol Hepatol. (2017);4(2):285- 297.

Hu MD, Edelblum KL; Sentinels at the Frontline: the Role of Intraepithelial lymphocytes in Inflammatory Bowel Disease. Current Pharmacology Reports 3(6):321-334, 2017

Pearce SC, Al-Jawadi A, Kishida K, Yu S, Hu MD, Fritzky LF, Edelblum KL, Gao N, Ferraris RP; Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types. BMC Biology. 2018 Feb 1;16(1):19.

Hu MD, Jia L, Edelblum KL; Policing the intestinal epithelial barrier: innate immune functions of intraepithelial lymphocytes. Current Pathobiology Reports. 2018 Mar;6(1):35-46.

Hu MD, Ethridge AD, Lipstein R, Kumar S, Wang Y, Jabri B, Turner JR, Edelblum KL; Epithelial IL-15 is a critical regulator of gd intraepithelial lymphocyte migration within the intestinal mucosa. J Immunol. 2018 Jul 15;201(2):747-756.

Areas Of Interest

Epithelial cell biology

Gastrointestinal biology

Immunology

Inflammation

ucosal immunology

Course List

PATH511AQ		Immunology - A
GSND5006Q		Grantsmanship Skills
GSND5200Q		Intro to Biomedical Sciences
TIII5022Q		Advanced Concepts in III

Investigating the role of gamma delta intraepithelial lymphocytes in mucosal immunity

Our lab focuses on understanding the role of gamma delta intraepithelial lymphocytes (IEL) interactions within the
intestinal epithelium in the regulation of mucosal innate immunity. We use both in vitro and in vivo models in conjuction
with state-of-the-art imaging techniques to identify how gamma delta IEL motility can be used as a potential therapeutic in
the treatment of inflammatory bowel disease.