Overview

Sridhar Kannurpatti received his PhD in Biophysics from the National Institute of Mental Health and Neurosciences (NIMHANS, India. His research and teaching interests within the Department of Radiology are in Radiologycal Physics, Biomedical and functional imaging in physiology and disease. His laboratory research specializes in the development and application of multi-modal structural and functional imaging of the brain in vivo in combination with preclinical behavioral, histochemical and neurochemical approaches.

Education

PHD, 2000, National Institute of Mental Health and Neurosciences, India
MPHIL, 1995, National Institute of Mental Health and Neurosciences, India
M.S., 1993, Bangalore University, India
B.S., 1991, St. Joseph's College, Bangalore Univ., India

Relevant Publications

SS. Kannurpatti, PG. Joshi, NB. Joshi. Calcium sequestering ability of mitochondria modulates the calcium influx through glutamate receptor channel. Neurochem Res (2000) 25: 1527-1536. SS. Kannurpatti, BB. Biswal, AG. Hudetz. Regional dynamics of the fMRI-BOLD signal response to hypoxia-hypercapnia in the rat brain. J Magn Reson Imaging a(2003)17:641-7. SS Kannurpatti, BG. Sanganahalli, S. Mishra, PG. Joshi, NB. Joshi. Glutamate induced differential mitochondrial response in young and adult rats. NeurochemInt (2004) 44: 361-369.

SS. Kannurpatti, BB. Biswal. Negative functional response to sensory stimulation and its origins. J. Cereb Blood Flow Metab (2004) 24:703-712. SS. Kannurpatti, BB. Biswal.Spatial extent of CBF response during whisker stimulation using trial averaged laser Doppler Imaging. Brain Res (2006) 1089: 135-142.

BB. Biswal, SS. Kannurpatti, B. Rypma. Hemodynamic scaling of fMRI-BOLD signal: validation of low-frequency spectral amplitude as a scalability factor. Magnetic Resonance Imaging (2007) 25:1358-1369. SS. Kannurpatti, BB. Biswal, YR. Kim, BR. Rosen. Spatio Temporal Characteristics of Low Frequency BOLD Signal Fluctuations In Isoflurane Anesthetized Rat Brain. Neuroimage (2008) 40:1738-1747.

SS. Kannurpatti, BB.Biswal. Mitochondrial Ca2+uniporter blockers influence activation-induced CBF response in the rat somatosensory cortex. J.Cereb Blood Flow Metab (2008) 28:772-785. SS. Kannurpatti, BB. Biswal. Detection and scaling of task-induced fMRI-BOLD response using resting state fluctuations. Neuroimage (2008) 40:1567-1574.

SS. Kannurpatti, BB. Biswal, MA. Motes, B. Rypma. Neural and vascular variability and the fMRI-BOLD response in normal aging. Magn Reson Imaging (2010) 28:466-76. SS. Kannurpatti, BB. Biswal, MA Motes, B. Rypma. Increasing measurement accuracy of age-related BOLD signal change: Minimizing vascular contributions by resting-state-fluctuation-of-amplitude scaling. Human Brain Mapp (2011) 32:1125-40. SS. Kannurpatti, BB. Biswal. Frequency tuning in the rat whisker barrel cortex revealed through RBC flux maps. Brain Res (2011) 1417:16-26.

SS. Kannurpatti, BB. Biswal, MA Motes, B. Rypma. Non neural BOLD variability in blocked and event-related paradigms. MagnReson Imaging (2011) 29:140-146. SS. Kannurpatti, B. Rypma, BB. Biswal. Prediction of task-related BOLD fMRI with amplitude signatures of resting-state fMRI. Front. Syst. Neurosci (2012) 6:7.

BG. Sanganahalli, P. Herman, F. Hyder, SS. Kannurpatti *. Mitochondrial calcium uptake capacity modulates neocortical excitability. J Cereb. Blood. Flow. Metab (2013) 33:1115-26. BG. Sangahanalli, P. Herman, F. Hyder, SS. Kannurpatti *. Mitochondrial functional state impacts spontaneous neocortical activity and resting state fMRI. PLoS One (2013) May 1;8(5):e63317.

SS. Kannurpatti, BB. Biswal, MA. Motes, B. Rypma. Assessment of unconstrained cerebrovascular reactivity marker for large age-range fMRI studies. PLoS One (2014) Feb 13;9(2): e88751. SS. Kannurpatti, BG. Sangahanalli, P. Herman, F. Hyder.Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks. NMR Biomed (2015) 28:1579-1588. M. Murugan, V. Santhakumar, SS.Kannurpatti. Facilitating mitochondrial calcium uptake improves activation-induced cerebral blood flow and behavior after mTBI. Front Syst Neurosci (2016) Mar 8;10:19. doi: 10.3389/fnsys.2016.00019.

SS. Kannurpatti. Mitochondrial calcium homeostasis: Implications for neurovascular and neurometabolic coupling. J Cereb Blood Flow Metab (2016) Nov 22. pii: 0271678X16680637 M. Parent, Y. Li, V. Santhakumar, F. Hyder, B.G. Sanganahalli, SS. Kannurpatti* (2018). Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development. J Neurotrauma. 2018 Aug 13. doi: 10.1089/neu.2018.5741.

J. Chitturi, V. Santhakumar, SS.Kanurpatti* (2018). Early behavioral and metabolomic change after mild to moderate traumatic brain injury in the developing brain. Neurochem Int. 2018 Aug 9;120:75-86. doi: 10.1016/j.neuint.2018.08.003.

Areas Of Interest

PET

aging

brain

calcium uniporter

cerebral blood flow

epilepsy

fMRI

mitochondria

optical imaging

somatosensory cortex

translational imaging

traumatic brain injury

brain metabolism

My laboratory specializes in the development and applications of in vivo structural and fuctional neuroimaging (fMRI and Laser Doppler Imaging)to study brain function in physiology and disease. Specific areas include aging, traumatic brain injury, spinal cord injury and epilepsy.