International Center for Public Health (ICPH) 225 Warren Street Room
Phone: (973) 975-4530
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Overview
Education, Training, Positions:
PhD 1975, Indian Institute of Science, Bangalore, India
Research Fellow, 1974-76, Harvard University, Cambridge, MA
Assistant Research Scientist, 1976-78, New York University School of Medicine, New York,
NY
Assistant Professor (1979-1983); Associate Professor (1983-1989) and Professor (1989-
present), UMDNJ-New Jersey Medical School, Newark, NJ
Visiting Fellow (195-96), Princeton University, Princeton, NJ
Education
MSC, 1970, Madras University (JIPMER campus), Medical Biochemistry BSC, 1967, Andhra University (Loyola campus), Chemistry & Biology PHD, 1975, Indian Institute of Science, Biochemistry & Molecular Biology
Areas Of Interest
Course List
Fidelity of DNA replication
Most of my research has been on the molecular mechanisms of mutagenesis, using bacterial model organisms
such as Escherichia coli. My early career focused on mechanisms of mutagenesis by the natural carcinogen
aflatoxin, and the industrial carcinogens chloroacetaldehyde and vinyl chloride. In later years my research
focused on novel mutator phenotypes, including a pathway by which translational errors provoked a blow-back effect
on DNA replication fidelity ("Translational Stress-induced Mutagenesis", TSM). TSM provides insights into
unexpected mechanisms by which environmental conditions could alter mutation rates and speed-up evolution.
