About
- Academic Office:
Medical Science Building (MSB) 185 South Orange Avenue H582 Newark, NJ 07101
- Phone: 973-972-6614
CURRENT ACADEMIC APPOINTMENTS Assistant Professor, 2019 - Present Department of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Rutgers University, Newark, NJ Core Investigator, Brain Health Institute, 2019 - Present Rutgers University, Piscataway, NJ
Practice Locations
Education
BS, 1995, Korea University MS, 2001, Korea University, Seoul, Korea PHD, 2007, Baylor College of Medicine
Current Research
Crosstalk between the cerebrovascular system and the nervous system in Alzheimer's disease
Increasing evidence suggests that cerebrovascular dysfunction is one of the pathological hallmarks of Alzheimer's disease (AD). Many AD patients suffer from cerebral microinfarcts and a damaged cerebral vasculature, and a majority of patients with dementia present with both AD and vascular pathologies. However, the mechanism underlying the vascular contribution in AD is unclear. Our lab is interested in the crosstalk between the cerebrovascular system and the nervous system in AD. To identify molecular targets and biomarkers underlying cerebrovascular deficits in AD, we are investigating cerebrovascular dysfunction and blood-brain barrier damage in rodent AD models and postmortem specimens of AD patients using various biochemical & histochemical techniques, in vivo fiberoptic spectroscopy, in vivo two photon imaging, MRI, and 3D Immunostaining.
Publications
Arnab Choudhury, Metin Yesiltepe, Tammaryn Lashley, Vishal Singh, Tao Yin, Anllely Fernandez, Luciano D'Adamio, Hyung Jin Ahn (2025). 'Pathological Mechanisms of Motor Dysfunction in Familial Danish Dementia: Insights from a Knock-In Rat Model' Journal of Neuroinflammation, Accepted Vishal Singh, Arnab Choudhury, Hyung Jin Ahn (2025). 'Fibrinogen's potential role in connecting cerebrovascular abnormalities with glymphatic dysfunction in Alzheimer's disease' Neural Regeneration Research 20(1):p 203-204, January 2025. PMID: 39657091. Vishal Singh, Nicholas Rochakim, Francesca Ferraresso, Arnab Choudhury, Christian J Kastrup, Hyung Jin Ahn (2024). 'Caveolin-1 and Aquaporin-4 as Mediators of Fibrinogen-Driven Cerebrovascular Pathology in Hereditary Cerebral Amyloid Angiopathy' BioRxiv. PMID: 39605467. Daniel S Gareau, Nicholas RochaKim, Arnab Choudhury, Michael Bamkole, Matija Snuderl, Julia Zou, Anna Yaroslavsky, Steven L Jacques, Sidney Strickland, James G Krueger, Hyung Jin Ahn (2023). 'Fiberoptic hemodynamic spectroscopy reveals abnormal cerebrovascular reactivity in a freely moving mouse model of Alzheimer's disease' Frontier Mol. Neurosci, Volume 16 ' 2023. PMID: 37465366. Hanna E Berk-Rauch, Arnab Choudhury, Allison T Richards, Pradeep K Singh, Zu-Lin Chen, Erin H Norris, Sidney Strickland, Hyung Jin Ahn (2023). 'Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer's disease' Frontier. Aging Neurosci, Volume 15 ' 2023. PMID: 36967821. Nicholas M. Tataryn, Vishal Singh, Jonathan P. Dyke, Hanna E. Berk-Rauch, Dana Clausen, Eric Aronowitz, Erin H. Norris, Sidney Strickland, Hyung Jin Ahn (2021) "Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease" Neurobiol. Aging, 107: 96-108 Steven A. Cajamarca, Erin H. Norris, Louise van der Weerd, Sidney Strickland, Hyung Jin Ahn. (2020) "Cerebral amyloid angiopathy-linked beta-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen." Proc. Natl. Acad. Sci, 117: 14482-14492. Hyung Jin Ahn, Sarah K. Baker, Erin H. Norris, Sidney Strickland (2019) "Inflaming the Brain." Neuron, 101:991-993 Pradeep K. Singh, Masanori Kawasaki, Hanna E. Berk-Rauch, Michael A. Foley, Erin H. Norris, Sidney Strickland, Kazuyoshi Aso, Hyung Jin Ahn (2018) "Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Abeta?Fibrinogen Interaction and Abeta-Induced Contact System Activation." Biochemistry, 57: 1399-1409 Hyung Jin Ahn, Zu-Lin Chen, Daria Zamolodchikov, Erin H. Norris, Sidney Strickland (2017) "Interactions of Beta-Amyloid Peptide with Fibrinogen and Coagulation Factor XII may contribute to Alzheimer's Disease." Curr Opin Hematol, 24: 427-431