About
- Academic Office:
Medical Science Building (MSB) 185 South Orange Avenue H582 Newark, NJ 07101
- Phone: 973-972-6614
CURRENT ACADEMIC APPOINTMENTS Assistant Professor, 2019 - Present Department of Pharmacology, Physiology & Neuroscience New Jersey Medical School, Rutgers University, Newark, NJ Core Investigator, Brain Health Institute, 2019 - Present Rutgers University, Piscataway, NJ
Practice Locations
Education
MS, 2001, Korea University, Seoul, Korea PHD, 2007, Baylor College of Medicine
Current Research
Crosstalk between the cerebrovascular system and the nervous system in Alzheimer's disease
Increasing evidence suggests that cerebrovascular dysfunction is one of the pathological hallmarks of Alzheimer's disease (AD). Many AD patients suffer from cerebral microinfarcts and a damaged cerebral vasculature, and a majority of patients with dementia present with both AD and vascular pathologies. However, the mechanism underlying the vascular contribution in AD is unclear. Our lab is interested in the crosstalk between the cerebrovascular system and the nervous system in AD. To identify molecular targets and biomarkers underlying cerebrovascular deficits in AD, we are investigating cerebrovascular dysfunction and blood-brain barrier damage in rodent AD models and postmortem specimens of AD patients using various biochemical & histochemical techniques, in vivo fiberoptic spectroscopy, in vivo two photon imaging, MRI, and 3D Immunostaining.
Publications
Nicholas M. Tataryn, Vishal Singh, Jonathan P. Dyke, Hanna E. Berk-Rauch, Dana Clausen, Eric Aronowitz, Erin H. Norris, Sidney Strickland, Hyung Jin Ahn (2021) "Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease" Neurobiol. Aging, 107: 96-108 Steven A. Cajamarca, Erin H. Norris, Louise van der Weerd, Sidney Strickland, Hyung Jin Ahn. (2020) "Cerebral amyloid angiopathy-linked beta-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen." Proc. Natl. Acad. Sci, 117: 14482-14492. Hyung Jin Ahn, Sarah K. Baker, Erin H. Norris, Sidney Strickland (2019) "Inflaming the Brain." Neuron, 101:991-993 Pradeep K. Singh, Masanori Kawasaki, Hanna E. Berk-Rauch, Michael A. Foley, Erin H. Norris, Sidney Strickland, Kazuyoshi Aso, Hyung Jin Ahn (2018) "Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Abeta?Fibrinogen Interaction and Abeta-Induced Contact System Activation." Biochemistry, 57: 1399-1409 Hyung Jin Ahn, Zu-Lin Chen, Daria Zamolodchikov, Erin H. Norris, Sidney Strickland (2017) "Interactions of Beta-Amyloid Peptide with Fibrinogen and Coagulation Factor XII may contribute to Alzheimer's Disease." Curr Opin Hematol, 24: 427-431 Daria Zamolodchikov, Hanna E. Berk-Rauch, Deena A. Oren, Daniel S. Stor, Pradeep K. Singh, Kazuyoshi Aso, Sidney Strickland, Hyung Jin Ahn (2016) "Biochemical and Structural Analysis of the Interaction between Beta-Amyloid and Fibrinogen." Blood, 128:1144-1151, Featured on the Cover Hyung Jin Ahn, Fraser Glickman, Kai Lai Poon, Daria Zamolodchikov, Odella C. Jno- Charles, Erin H. Norris, Sidney Strickland (2014) "A novel Abeta-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice." J Exp Med, 211: 1049-1062, Highlighted in Nature Reviews Drug Discovery and featured on faculty of 1000 Hyung Jin Ahn, Daria Zamolodchikov, Marta Cortes-Canteli, Erin H. Norris, J. Fraser Glickman, Sidney Strickland (2010) "The Alzheimer's Disease peptide Beta-Amyloid Interacts with Fibrinogen and Induces its Oligomerization" Proc. Natl. Acad. Sci. USA, 107: 21812-21817 Marta Cortes-Canteli, Justin Paul, Erin H. Norris, Robert Bronstein, Hyung Jin Ahn, Daria Zamolodchikov, Shivaprasad Bhuvanendran, Katherine M. Fenz, Sidney Strickland (2010) "Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease." Neuron, 66: 695-709 Hyung Jin Ahn, Cateria Hernandez, Jonathan M. Levenson, Farah Lubin, Hsiou-Chi Liou, J. David Sweatt. (2008) "c-Rel, an NF-kB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation." Learn Mem, 15: 539-549; Featured on the Cover